Inhibition, Not Excitation, Drives Rhythmic Whisking.
Inhibition, Not Excitation, Drives Rhythmic Whisking.
复制标题
DOI：
10.1016/j.neuron.2016.03.007
复制
发表时间：
2016-04-20
期刊：
影响因子：
16.2
通讯作者：
Kleinfeld D
中科院分区：
文献类型：
--
作者：
Deschênes M;Takatoh J;Kurnikova A;Moore JD;Demers M;Elbaz M;Furuta T;Wang F;Kleinfeld D
嗅闻和搅拌是啮齿类动物的典型探索行为。这些作用涉及骨髓中单独的振荡器，分别位于前Bötinger复合体（preBötC）和中间网状结构（vIRt）的触须相关区域。我们研究这些振荡器如何协同控制嗅探和搅拌。我们发现vIRt含有甘氨酸能/GABA能细胞，其有节奏地抑制触须面部运动神经元。作为基础的夹带搅拌呼吸，但不是反之亦然，我们提供的证据，单向连接的preBötC的vIRt。preBötC进一步有助于控制mystyrene垫。最后，我们表明，双边同步搅拌依赖于呼吸节律，与前BötC细胞之间的连合连接。这些数据产生了一个假定的电路，其中preBötC作为一个主时钟的触须，垫和吻运动的同步，以及双边同步搅拌。
Sniffing and whisking typify the exploratory behavior of rodents. These actions involve separate oscillators in the medulla, located respectively in the pre-Bötzinger complex (preBötC) and the vibrissa-related region of the intermediate reticular formation (vIRt). We examine how these oscillators synergize to control sniffing and whisking. We find that the vIRt contains glycinergic/GABAergic cells that rhythmically inhibit vibrissa facial motoneurons. As a basis for the entrainment of whisking by breathing, but not vice versa, we provide evidence for unidirectional connections from the preBötC to the vIRt. The preBötC further contributes to the control of the mystacial pad. Lastly, we show that bilateral synchrony of whisking relies on the respiratory rhythm, consistent with commissural connections between preBötC cells. These data yield a putative circuit in which the preBötC acts as a master clock for the synchronization of vibrissa, pad and snout movements, as well as for the bilateral synchronization of whisking.