Microtubules as Major Regulators of Endothelial Function: Implication for Lung Injury.
Microtubules as Major Regulators of Endothelial Function: Implication for Lung Injury.
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DOI：
10.3389/fphys.2021.758313
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发表时间：
2021
影响因子：
4
通讯作者：
Birukova AA
中科院分区：
文献类型：
--
作者：
Karki P;Birukova AA
内皮功能障碍被认为是COVID-19患者的主要并发症之一，这一全球大流行已在全球造成400多万人死亡。内皮屏障功能障碍的特点是内皮通透性和炎症反应增加，在急性呼吸综合征（ARDS）、败血症和以肺动脉高压和间质性肺疾病为代表的慢性疾病的发病机制中具有更广泛的意义。内皮屏障的结构完整性是由细胞骨架元件、细胞-基质黏附和黏附细胞连接维持的。激动剂介导的内皮通透性改变与肌动蛋白细胞骨架的重组直接相关，导致细胞收缩和细胞间隙的打开，或皮质肌动蛋白细胞骨架的增强与内皮屏障的增强有关。肌动蛋白细胞骨架重塑在内皮屏障调节中的作用已经占据了中心位置，但微管在这一过程中的影响仍然很少被探索和低估。本文综述了微管动力学与肌动蛋白细胞骨架重塑之间的串扰，描述了介导这种串扰的信号机制，讨论了微管稳定性的表观遗传调控及其与内皮屏障维持的关系，并概述了微管在靶向传递调节内皮通透性和炎症的信号分子中的作用。
Endothelial dysfunction has been attributed as one of the major complications in COVID-19 patients, a global pandemic that has already caused over 4 million deaths worldwide. The dysfunction of endothelial barrier is characterized by an increase in endothelial permeability and inflammatory responses, and has even broader implications in the pathogenesis of acute respiratory syndromes such as ARDS, sepsis and chronic illnesses represented by pulmonary arterial hypertension and interstitial lung disease. The structural integrity of endothelial barrier is maintained by cytoskeleton elements, cell-substrate focal adhesion and adhesive cell junctions. Agonist-mediated changes in endothelial permeability are directly associated with reorganization of actomyosin cytoskeleton leading to cell contraction and opening of intercellular gaps or enhancement of cortical actin cytoskeleton associated with strengthening of endothelial barrier. The role of actin cytoskeleton remodeling in endothelial barrier regulation has taken the central stage, but the impact of microtubules in this process remains less explored and under-appreciated. This review will summarize the current knowledge on the crosstalk between microtubules dynamics and actin cytoskeleton remodeling, describe the signaling mechanisms mediating this crosstalk, discuss epigenetic regulation of microtubules stability and its nexus with endothelial barrier maintenance, and overview a role of microtubules in targeted delivery of signaling molecules regulating endothelial permeability and inflammation.
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影响因子：
64.5
作者：
Fukata, M;Watanabe, T;Kaibuchi, K
通讯作者：
Kaibuchi, K
影响因子：
64.8
作者：
Hubbert, C;Guardiola, A;Yao, TP
通讯作者：
Yao, TP
DOI：
10.1165/rcmb.2015-0149oc
发表时间：
2016-05-01
影响因子：
6.4
作者：
Borgas, Diana;Chambers, Eboni;Lu, Qing
通讯作者：
Lu, Qing
影响因子：
4.8
作者：
Birukova, AA;Birukov, KG;Verin, AD
通讯作者：
Verin, AD
影响因子：
4.8
作者：
Amano, M;Ito, M;Kaibuchi, K
通讯作者：
Kaibuchi, K