Voluntary Physical Exercise Alters Attentional Orienting and Social Behavior in a Rat Model of Attention-Deficit/Hyperactivity Disorder
Voluntary Physical Exercise Alters Attentional Orienting and Social Behavior in a Rat Model of Attention-Deficit/Hyperactivity Disorder
复制标题
DOI：
10.1037/a0015632
复制
发表时间：
2009-06-01
影响因子：
1.9
通讯作者：
Bucci, David J.
中科院分区：
文献类型：
--
作者：
Hopkins, Michael E.;Sharma, Mita;Bucci, David J.
研究了自发性高血压大鼠（SHR）（一种常用的注意力缺陷/多动障碍（ADHD）动物模型）的注意功能和社会行为的影响。运动组的大鼠在两周内可以自由地进入跑步轮，然后在第一次训练期间，所有大鼠都接受了非强化的视觉刺激（光），随后的日常训练中，光与食物搭配。非运动的雄性和雌性SHR大鼠比Wistar-Kyoto大鼠表现出更多的无条件定向行为。当光与食物搭配时，SHRs也表现出了受损的调节能力。运动降低了女性SHRs的定向，但对男性SHRs没有影响。在社会互动任务中，与Wistar-Kyoto大鼠相比，未运动的雄性和雌性SHRs与不熟悉的大鼠的互动更多。运动减少了女性shr患者的社交次数，但男性shr患者没有。在非运动组和运动组之间，一般运动活动没有观察到差异。这些数据表明，运动可能优先有利于女性SHRs，并对将运动作为ADHD的干预手段以及理解运动对行为影响的性别差异具有启示意义。
The effects of voluntary physical exercise on attentional function and social behavior were examined in male and female spontaneously hypertensive rats (SHR), a commonly used animal model of attention-deficit/hyperactivity disorder (ADHD). Rats in the exercise groups had free access to a running wheel for 2 weeks and then all rats received nonreinforced presentations of a visual stimulus (light) during the 1st training session, followed by daily sessions in which the light was paired with food. Nonexercising male and female SHR rats exhibited more unconditioned orienting behavior than Wistar-Kyoto rats. SHRs also exhibited impaired conditioning when the light was paired with food. Exercise reduced orienting in female SHRs but not in male SHRs. In the social interaction task, nonexercising male and female SHRs interacted more with an unfamiliar rat than Wistar-Kyoto rats. Exercise reduced the number of social interactions in female SHRs but not male SHRs. There were no differences in general locomotor activity observed between the nonexercising and exercising SHRs. These data indicate that exercise may preferentially benefit female SHRs, and has implications for using exercise as an intervention for ADHD and for understanding sex differences in the effects of exercise on behavior.