Preparation of nanofibers containing the microalga Spirulina (Arthrospira)
Preparation of nanofibers containing the microalga Spirulina (Arthrospira)
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DOI：
10.1016/j.biortech.2009.11.059
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发表时间：
2010-04-01
影响因子：
11.4
通讯作者：
Wendorff, Joachim
中科院分区：
文献类型：
--
作者：
de Morais, Michele Greque;Stillings, Christopher;Wendorff, Joachim
螺旋藻是一种具有良好生物学功能的微生物，对组织工程具有重要意义。含有螺旋藻生物质的高多孔支架可以通过静电纺丝制备。因此，该贡献的目标是建立纺丝条件，允许产生直径低至约100 nm的良好限定的纳米纤维，并产生具有各种浓度的生物质的纳米纤维，用于组织工程应用中的后续研究。实验结果表明，PEO/生物质共混体系在静电纺丝中表现出令人惊讶的良好性能。对于高达67重量%的不同生物质含量，可以生产直径约110 nm的非常薄的无珠纳米纤维的纳米纤维和纺丝溶液中的PEO浓度远低于4重量%。这些结果向我们建议使用含有纳米纤维的生物质作为干细胞培养和脊髓损伤的未来治疗的细胞外基质。(C)2009爱思唯尔有限公司保留所有权利。
Spirulina is a microalga which offers biological functions highly favorable for tissue engineering. Highly porous scaffolds can be produced by electrospinning containing biomass of Spirulina. The goal of this contribution was therefore to establish spinning conditions allowing to produce well defined nanofibers with diameters down to about 100 nm and to produce nanofibers with various concentration of the biomass for subsequent studies in tissue engineering applications. The experimental results reveal that the blend system PEO/biomass is behaved surprisingly well in electrospinning. Very thin bead-free nanofibers with diameters of about 110 nm can be produced for different biomass contents of up to 67 wt.% of the nanofibers and for PEO concentrations in the spinning solution well below 4 wt.%. These results suggest to us the use of the biomass containing nanofibers as extracellular matrices for stem cell culture and future treatment of spinal chord injury. (C) 2009 Elsevier Ltd. All rights reserved.