What is the best way to measure renal fibrosis?: A pathologist's perspective.
What is the best way to measure renal fibrosis?: A pathologist's perspective.
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测量肾纤维化的最佳方法是什么？：病理学家的观点。
DOI：
10.1038/kisup.2014.3
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发表时间：
2014-11
影响因子：
5.5
通讯作者：
Alpers CE
中科院分区：
文献类型：
--
作者：
Farris AB;Alpers CE
间质纤维化是进行性和慢性肾脏疾病的标志性结构相关性。关于如何在研究环境中以及在为个体患者管理而进行的肾活检评估中最好地测量间质纤维化仍然存在许多不确定性。不确定性的领域包括确定纤维化实质中基质的组成，纤维化损伤如何涉及肾小管的定义，用于评价肾纤维化的组织学染色的选择，以及病理学家目前采用的措施的可重复性和稳健性，无论是否有计算机成像和评估的帮助。在这篇评论中，我们解决了其中的一些问题，同时引用了说明这些困难的关键研究。我们指出，未来的方法，可能会允许一个更准确和有意义的评估肾间质纤维化。
Interstitial fibrosis is a hallmark structural correlate of progressive and chronic kidney disease. There remain many uncertainties about how to best measure interstitial fibrosis both in research settings and in evaluations of renal biopsies performed for management of individual patients. Areas of uncertainty include determination of the composition of the matrix in a fibrotic parenchyma, the definition of how the interstitium is involved by fibrosing injuries, the choice of histologic stains for evaluation of renal fibrosis, and the reproducibility and robustness of measures currently employed by pathologists, both with and without the assistance of computerized imaging and assessments. In this review, we address some of these issues while citing the key studies that illustrate these difficulties. We point to future approaches that may allow a more accurate and meaningful assessment of renal interstitial fibrosis.