Infiltration of thymidine phosphorylase-positive macrophages is closely associated with tumor angiogenesis and survival in intestinal type gastric cancer
Infiltration of thymidine phosphorylase-positive macrophages is closely associated with tumor angiogenesis and survival in intestinal type gastric cancer
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DOI：
10.3892/or_00000873
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发表时间：
2010-08-01
期刊：
影响因子：
4.2
通讯作者：
Ono, Mayumi
中科院分区：
文献类型：
--
作者：
Kawahara, Akihiko;Hattori, Satoshi;Ono, Mayumi
胸苷磷酸化酶（TP）是一种催化胸苷、脱氧尿苷及其类似物在其各自碱基和2-脱氧核糖-1-磷酸处可逆磷酸化的酶，从而促进血管生成，其通常在肿瘤基质中存在的巨噬细胞中表达。在这项研究中，我们研究了TP阳性巨噬细胞以及肿瘤相关巨噬细胞的浸润是否影响肿瘤血管生成。TP在人巨噬细胞样细胞中表达，而在培养的胃癌细胞中不表达。应用免疫组化方法检测111例胃癌组织中TP的表达水平、浸润的CD 68（+）和CD 163（+）巨噬细胞数及微血管密度（MVD）。图像分析数字化数据的生物统计学分析显示，肠型胃癌中TP表达与浸润的巨噬细胞数量和MVD显著相关（p
Thymidine phosphorylase (TP), an enzyme catalyzing the reversible phospholysis of thymidine, deoxyuridine and their analogs at their respective bases and 2-deoxyribose-1-phosphate, thus promoting angiogenesis, is often expressed in macrophages present in tumor stroma. In this study, we investigated whether infiltration of TP-positive macrophages as well as tumor-associated macrophages affected tumor angiogenesis. TP was expressed in human macrophage-like cells, but not in gastric cancer cells in culture. The expression level of TP, the number of infiltrating CD68(+) and CD163(+) macrophages, and microvessel density (MVD) in the tumor were further analyzed by immunohistochemistry in 111 patients with gastric cancer. Biostatistical analysis of digitized data obtained by image analysis showed that TP expression was significantly correlated with the number of infiltrating macrophages and MVD in intestinal type gastric cancer (p