Tumors sound the alarmin(s).
Tumors sound the alarmin(s).
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DOI：
10.1158/0008-5472.can-08-0044
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发表时间：
2008-08-15
期刊：
影响因子：
11.2
通讯作者：
Scandurro AB
中科院分区：
文献类型：
--
作者：
Coffelt SB;Scandurro AB
最近的证据表明，炎症分子在众多肿瘤的发育和进展中起着关键作用，但是，在癌症生物学的功能中，一种特定的炎症分子在宿主免疫反应中的重要性很大程度上被忽略了这里讨论了几种警报，包括防御素，LL-37和HMGB1 - 在肿瘤的发展，进展或抑制中都讨论了这些研究。
Recent evidence suggests that inflammatory molecules play critical roles in the development and progression of numerous tumors. However, one specific group of inflammatory molecules whose importance has been established in host immune responses, termed alarmins, has been largely overlooked in cancer biology. The function of several alarmins—including the defensins, LL-37, and HMGB1—in tumor development, progression, or suppression is discussed here. Taken together, these studies indicate that alarmins represent potential new targets for manipulation in a variety of tumors.