Transplantation tolerance correlates with high levels of T- and B-lymphocyte activity.
Transplantation tolerance correlates with high levels of T- and B-lymphocyte activity.
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移植耐受性与高水平的 T 淋巴细胞和 B 淋巴细胞活性相关。
DOI：
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发表时间：
1989
影响因子：
11.1
通讯作者：
L. Forni
中科院分区：
文献类型：
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作者：
A. Bandeira;A. Coutinho;C. Carnaud;F. Jacquemart;L. Forni
通过注射半同种异体细胞使出生时对移植抗原耐受的小鼠在其脾脏中含有非常高数量的活化的T和B淋巴细胞。类风湿性关节炎活动过度与耐受状态相关：它仅存在于接受皮肤同种异体移植的动物中。排斥同种异体皮肤移植物的耐受小鼠具有与正常小鼠大致相同数量的总淋巴细胞和活化淋巴细胞。高水平的淋巴细胞活化耐受小鼠持续长达1岁，虽然它随着年龄的增长而下降，并显着增加了二次同种异体移植。原发性和继发性耐受反应的幅度均显著高于正常小鼠排斥同种异体移植物的免疫反应。这些观察结果与克隆缺失或无反应性概念相矛盾，这些概念是胚胎诱导移植耐受的基础，可能有助于实验和控制移植反应的其他方法。
Mice tolerized (treated to make them tolerant) at birth to transplantation antigens by injection of semiallogeneic cells contain very high numbers of activated T and B lymphocytes in their spleen. Lymphoid hyperactivity correlates with the tolerant state: it is present only in animals accepting skin allografts. Tolerized mice that reject the allogeneic skin graft have approximately the same numbers of total and activated lymphocytes as normal mice. The high level of lymphocyte activation in tolerant mice persists for up to 1 year of age, although it declines with age, and is markedly increased by a secondary allograft. The magnitudes of both primary and secondary tolerant responses are significantly higher than the immunological response of a normal mouse rejecting the same type of allograft. These observations contradict concepts of clonal deletion or anergy as the basis of neonatally induced transplantation tolerance and may contribute additional approaches to experimentation and control of transplantation reactions.