Tracheal aspirate VEGF and sphingolipid metabolites in the preterm infant with later development of bronchopulmonary dysplasia
Tracheal aspirate VEGF and sphingolipid metabolites in the preterm infant with later development of bronchopulmonary dysplasia
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DOI：
10.1002/ppul.24022
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发表时间：
2018-08-01
影响因子：
3.1
通讯作者：
Voynow, Judith A.
中科院分区：
文献类型：
--
作者：
Hendricks-Munoz, Karen D.;Xu, Jie;Voynow, Judith A.
目的血管内皮生长因子（VEGF）、鞘脂代谢物鞘磷脂1-磷酸（S1P）和神经酰胺在肺发育和修复中起重要作用。我们假设特异性鞘脂和VEGF的改变与BPD的发展有关，并旨在探讨早期气管吸入（TA） VEGF和S1P与早产儿支气管肺发育不良（BPD）后期诊断的关系。在婴儿TA中测量VEGF和脂质组学
ObjectiveVascular endothelial growth factor (VEGF) and sphingolipid metabolites, sphingosine 1-phosphate (S1P), and ceramides are important to lung development and repair. We hypothesized specific sphingolipid and VEGF alterations would be associated with BPD development and aimed to investigate the early tracheal aspirate (TA) VEGF and S1P relationship with later diagnosis of preterm infant bronchopulmonary dysplasia, BPD.DesignTA VEGF and lipidomics were measured in TA from Infants