Effects of catecholamines on lactic acid output during progressive working contractions.
Effects of catecholamines on lactic acid output during progressive working contractions.
复制标题
儿茶酚胺对进行性工作收缩期间乳酸输出的影响。
DOI：
10.1152/jappl.1985.59.6.1809
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Eitzman,PD
中科院分区：
文献类型：
--
作者：
Stainsby,WN;Sumners,C;Eitzman,PD
肾上腺素和去甲肾上腺素一起（E + NE）和肾上腺素（E）单独静脉输注，剂量逐步增加，在进行性等张强直收缩。我们的目标是模仿，在原位狗骨骼肌，这些儿茶酚胺在血液中的浓度和渐进运动过程中的收缩。测定动脉血和肌静脉血中乳酸和O2浓度、动脉血浆E和NE浓度、动脉血和肌静脉血中PO 2浓度以及静脉流出量。输注引起血浆E和NE升高，就像在渐进式运动中看到的那样。与不输注对照组相比，E + NE输注和E单独输注导致收缩期间肌肉的最大乳酸输出量显著增加，从对照组的0.24 mumol X g-1 X min-1分别增加到E + NE和E单独输注期间的0.44和0.54 mumol X g-1 X min-1。静脉O2浓度和分压并没有因输注而降低。两种输注均导致动脉乳酸浓度升高，这不能由收缩肌肉的乳酸输出来解释。E单独输注与收缩期间最大O2摄取的增加相关。由于E + NE和单独E输注的效果相似，因此表明E比NE更有活性。有人认为，E也增加了乳酸生产的组织以外的工作肌肉。
Epinephrine and norepinephrine together (E + NE) and epinephrine (E) alone were infused intravenously in stepwise increasing doses during progressive isotonic tetanic contractions. The goal was to mimic, for in situ dog skeletal muscle, the concentrations of these catecholamines in the blood and the contractions during progressive exercise. The concentrations of lactate and O2 in arterial and muscle venous blood, the arterial plasma concentration of E and NE, PO2 in arterial and muscle venous blood, and the venous outflow were measured. The infusions caused a rise in plasma E and NE like those seen in progressive exercise. Compared with no-infusion controls, the E + NE infusions and the E alone infusion resulted in significant increases in maximal lactic acid output by the muscles during the contractions from 0.24 mumol X g-1 X min-1 in the controls to 0.44 and 0.54 mumol X g-1 X min-1 during E + NE and E alone infusions, respectively. The venous O2 concentrations and partial pressures were not reduced by the infusions. Both infusions resulted in a rise of arterial lactate concentration that could not be accounted for by the lactic acid output of the contracting muscles. The E alone infusions were associated with a rise in maximal O2 uptake during the contractions. Since the effects of the E + NE and E alone infusions were similar, it was suggested that E is more active than NE. It was suggested that E also increased lactic acid production in tissues other than the working muscles.