Cellular plasticity in cardiovascular development and disease.
Cellular plasticity in cardiovascular development and disease.
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DOI：
10.1002/dvdy.24486
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发表时间：
2017-04
期刊：
影响因子：
--
通讯作者：
Red-Horse K
中科院分区：
文献类型：
--
作者：
Das S;Red-Horse K
关于细胞分化途径的知识对于理解器官发育、稳态和疾病至关重要。在这些背景下研究细胞分化和细胞命运限制可以通过谱系追踪实验来完成，这需要永久标记细胞及其所有后代。最近在心血管系统中的谱系实验发现了器官发生过程中细胞起源和疾病期间细胞可塑性的意外发现。例如，越来越多的证据表明，单一细胞类型存在多种祖细胞来源，并且细胞在疾病环境下具有显著的扩展能力。在这里，我们总结了心血管系统的一些最新发现，并强调有证据表明，潜在的概念是一个广泛的现象，被其他器官系统使用。
Knowledge on cellular differentiation pathways is critical to understanding organ development, homeostasis, and disease. Studying cell differentiation and cell fate restrictions in these contexts can be done through lineage tracing experiments, which entail permanent labeling of a cell and all its progeny. Recent lineage experiments within the cardiovascular system have uncovered unexpected findings on cellular origins during organogenesis and cell plasticity during disease. For example, there is increasing evidence that multiple progenitor sources exist for a single cell type, and that cells have remarkable expansive capacities under disease settings. Here, we summarize some recent findings in the cardiovascular system and highlight where there is evidence that the underlying concepts are a widespread phenomenon used by other organ systems.