10-year Cognition in Preterms After Random Assignment to Fatty Acid Supplementation in Infancy
10-year Cognition in Preterms After Random Assignment to Fatty Acid Supplementation in Infancy
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DOI：
10.1542/peds.2010-3153
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发表时间：
2011-10-01
期刊：
影响因子：
8
通讯作者：
Fewtrell, Mary S.
中科院分区：
文献类型：
--
作者：
Isaacs, Elizabeth B.;Ross, Sarah;Fewtrell, Mary S.
目的：为了检验这一假设，即在婴儿期补充长链多不饱和脂肪酸（LCPUFA）将提高认知到儿童后期（9年后）在一般和具体level.METHODS：一个全面的认知电池完成了107个以前的早产儿（平均年龄：128个月）。作为婴儿，他们被随机分配接受LCPUFA补充（N = 50）或对照（N = 57）配方奶粉，从出生到9个月;补充配方奶粉中的二十二碳六烯酸（DHA）水平为0.5%。除了随机比较，我们计划进行补充分析，以检查性别和喂养组（那些接受一些母亲母乳与那些没有收到）的影响。结果：有随机饮食组之间的任何认知措施没有显着差异。性别和补充剂之间存在显著的相互作用;只有女孩显示出LCPUFA对识字的有益影响。喂养组和补充组之间也发生了显著的相互作用;发现LCPUFA组的言语智商、全量表智商和记忆分数增加了0.7 SD，但仅适用于只接受配方奶粉而不接受母乳的婴儿。这项为期9年的认知随访研究的结果是一项LCPUFA随机试验，对早产儿补充配方奶的研究表明，总体上没有群体效应，但表明可能存在性别特异性和饮食特异性效应。这些数据提供了一些证据，表明LCPUFA是母乳认知益处的关键因素。由于使用的组较小，因此建议在数据解释时谨慎。儿科2011;128：e890-e898
OBJECTIVE: To test the hypothesis that long-chain polyunsaturated fatty acid (LCPUFA) supplementation in infancy would improve cognition into later childhood (after 9 years) at both general and specific levels.METHODS: A comprehensive cognitive battery was completed by 107 formerly preterm infants (mean age: 128 months). As infants, they had been assigned randomly to receive LCPUFA-supplemented (N = 50) or control (N = 57) formula, between birth and 9 months; the docosahexaenoic acid level (DHA) in the supplemented formulas was 0.5%. In addition to randomized comparisons, we planned supplementary analyses to examine the effects of both gender and feeding group (those receiving some maternal breast milk versus those receiving none).RESULTS: There were no significant differences between randomized diet groups on any cognitive measure. There was significant interaction between gender and supplementation; girls only showed beneficial effects of LCPUFAs on literacy. Significant interaction also occurred between feeding group and supplementation; increases of 0.7 SD in verbal IQ, full-scale IQ, and memory scores were found for the LCPUFA group, but only for infants who received only formula and no maternal breast milk.CONCLUSIONS: The results of this post-9-year cognitive follow-up study in a randomized trial of LCPUFA-supplemented formula for preterm infants suggest no overall group effects but indicate that gender-specific and diet-specific effects may exist. The data provide some evidence that LCPUFAs are a key factor in the cognitive benefits of breast milk. Caution is advised in data interpretation because of the small groups used. Pediatrics 2011;128:e890-e898