The free-radical theory of ageing - older, wiser and still alive Modelling positional effects of the primary targets of ROS reveals new support
The free-radical theory of ageing - older, wiser and still alive Modelling positional effects of the primary targets of ROS reveals new support
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DOI：
10.1002/bies.201200014
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发表时间：
2012-08-01
期刊：
影响因子：
4
通讯作者：
Kowald, Axel
中科院分区：
文献类型：
--
作者：
Kirkwood, Thomas B. L.;Kowald, Axel
自由基老化理论的持续可行性受到质疑，最近的结果显然不一致。我们通过模拟位置效应的产生和主要目标的活性氧物种，许多明显的负面结果很可能是误导。我们的结论是，相反，有必要更密切地关注自由基有助于生活系统中与年龄相关的功能障碍的机制。还需要更深入地了解各种分子损伤，特别是mtDNA突变的积累和消除的动态。最后，自由基损伤本身可能导致衰老的期望需要放弃，而应该承认自由基理论只是驱动衰老过程的多种机制之一。
The continuing viability of the free-radical theory of ageing has been questioned following apparently incompatible recent results. We show by modelling positional effects of the generation and primary targets of reactive oxygen species that many of the apparently negative results are likely to be misleading. We conclude that there is instead a need to look more closely at the mechanisms by which free radicals contribute to age-related dysfunction in living systems. There also needs to be deeper understanding of the dynamics of accumulation and removal of the various kinds of molecular damage, in particular mtDNA mutations. Finally, the expectation that free-radical damage on its own might cause ageing needs to be relinquished in favour of the recognition that the free-radical theory is just one of the multiple mechanisms driving the ageing process.