Why sleep is important for health: a psychoneuroimmunology perspective.
Why sleep is important for health: a psychoneuroimmunology perspective.
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DOI：
10.1146/annurev-psych-010213-115205
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发表时间：
2015-01-03
影响因子：
24.8
通讯作者：
Irwin MR
中科院分区：
文献类型：
--
作者：
Irwin MR
睡眠在促进健康方面起着关键作用。过去十年的研究证明，睡眠障碍对感染疾病的风险、包括心血管疾病和癌症在内的几种主要疾病的发生和发展以及抑郁症的发生率具有强大的影响。该领域越来越多地将重点放在确定这些效应背后的生物学机制上。本文着重介绍睡眠对适应性免疫和先天免疫的影响，包括睡眠障碍、睡眠受限和失眠对抗病毒免疫反应和疫苗反应及传染病风险的影响，以及对促炎症免疫反应与心血管疾病、癌症和抑郁症的影响。本文还讨论了神经内分泌和自主神经基础联系睡眠障碍和免疫，以及睡眠和炎症生物学之间的相互联系。最后讨论了作为改善睡眠的有效策略的干预措施，并确定了促进睡眠健康的潜在机会，以用于慢性传染病、炎症性疾病和神经精神疾病的治疗控制。
Sleep has a critical role in promoting health. Research over the past decade has documented that sleep disturbance has a powerful influence on the risk of infectious disease, the occurrence and progression of several major medical illnesses including cardiovascular disease and cancer, and the incidence of depression. Increasingly, the field has focused on identifying the biological mechanisms underlying these effects. This review highlights the impact of sleep on adaptive and innate immunity, with consideration of the dynamics of sleep disturbance, sleep restriction, and insomnia on antiviral immune responses with consequences for vaccine responses and infectious disease risk, and on proinflammatory immune responses with implications for cardiovascular disease, cancer, and depression. This review also discusses the neuroendocrine and autonomic neural underpinnings linking sleep disturbance and immunity, and the reciprocal links between sleep and inflammatory biology. Lastly interventions are discussed as effective strategies to improve sleep, and potential opportunities are identified to promote sleep health for therapeutic control of chronic infectious, inflammatory, and neuropsychiatric diseases.