The Role of DNA Methylation in Renal Cell Carcinoma.
The Role of DNA Methylation in Renal Cell Carcinoma.
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DOI：
10.1007/s40291-018-0337-9
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发表时间：
2018-08
影响因子：
4
通讯作者：
Brooks JD
中科院分区：
文献类型：
--
作者：
Lasseigne BN;Brooks JD
肾细胞癌（Renal cell carcinoma，RCC）是最常见的肾癌，包括几种具有不同临床特征的分子和组织学亚型。虽然如果RCC在仍然局限于肾脏时被诊断并得到明确治疗，则存活率很高，但没有特定的诊断筛查测试，并且在疾病的早期阶段症状很少。随着靶向治疗的出现，晚期RCC的管理发生了显着变化，但由于对这些治疗的获得性耐药性，生存期通常会增加数月。DNA甲基化，即甲基与胞嘧啶的共价加成，对正常发育和转录调控至关重要，但在癌症中通常会发生改变。这些改变导致广泛的转录变化，包括肿瘤抑制基因。由于DNA甲基化是癌症中最早的分子变化之一，并且广泛而稳定，因此其在癌症生物学中的作用，包括肾细胞癌，已被广泛研究。在这篇综述中，我们研究了DNA甲基化在肾细胞癌疾病病因和进展中的作用，DNA甲基化改变作为诊断，预后和预测生物标志物的临床前应用，以及DNA甲基化导向治疗的潜力。
Renal cell carcinoma (RCC) is the most common kidney cancer and includes several molecular and histological subtypes with different clinical characteristics. While survival rates are high if RCC is diagnosed when still confined to the kidney and treated definitively, there are no specific diagnostic screening tests available and symptoms are rare in early stages of the disease. Management of advanced RCC has changed significantly with the advent of targeted therapies, yet survival is usually increased by months due to acquired resistance to these therapies. DNA methylation, the covalent addition of a methyl group to a cytosine, is essential for normal development and transcriptional regulation, but becomes altered commonly in cancer. These alterations result in broad transcriptional changes, including in tumor suppressor genes. Because DNA methylation is one of the earliest molecular changes in cancer and is both widespread and stable, its role in cancer biology, including renal cell carcinoma, has been extensively studied. In this review we examine the role of DNA methylation in renal cell carcinoma disease etiology and progression, the preclinical use of DNA methylation alterations as diagnostic, prognostic and predictive biomarkers, and the potential for DNA methylation-directed therapies.
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影响因子：
14.9
作者：
NCBI Resource Coordinators
通讯作者：
NCBI Resource Coordinators
DOI：
10.1158/1078-0432.ccr-13-0491
发表时间：
2013-09-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Choueiri TK;Fay AP;Gagnon R;Lin Y;Bahamon B;Brown V;Rosenberg JE;Hutson TE;Baker-Neblett KL;Carpenter C;Liu Y;Pandite L;Signoretti S
通讯作者：
Signoretti S
影响因子：
--
作者：
Chopra S;Liu J;Alemozaffar M;Nichols PW;Aron M;Weisenberger DJ;Collings CK;Syan S;Hu B;Desai M;Aron M;Duddalwar V;Gill I;Liang G;Siegmund KD
通讯作者：
Siegmund KD
影响因子：
--
作者：
Fabrizio FP;Costantini M;Copetti M;la Torre A;Sparaneo A;Fontana A;Poeta L;Gallucci M;Sentinelli S;Graziano P;Parente P;Pompeo V;De Salvo L;Simone G;Papalia R;Picardo F;Balsamo T;Flammia GP;Trombetta D;Pantalone A;Kok K;Paranita F;Muscarella LA;Fazio VM
通讯作者：
Fazio VM
影响因子：
--
作者：
Faleiro I;Leão R;Binnie A;de Mello RA;Maia AT;Castelo-Branco P
通讯作者：
Castelo-Branco P