Computing maximum association graph in microscopic nucleus images.
Computing maximum association graph in microscopic nucleus images.
复制标题
计算显微核图像中的最大关联图。
DOI：
10.1007/978-3-642-15745-5_65
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Berezney,Ronald
中科院分区：
文献类型：
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作者：
Stojkovic,Branislav;Zhu,Yongding;Xu,Jinhui;Fritz,Andrew;Zeitz,MichaelJ;Vecerova,Jaromira;Berezney,Ronald
In this paper, we study the problem of finding organization patterns of chromosomes inside the cell nucleus from microscopic nucleus images. Emerging evidence from cell biology research suggests that global chromosome organization has a vital role in fundamental cell processes related to gene expression and regulation. To understand how chromosome territories are neighboring (or associated) to each other, in this paper we present a novel technique for computing a common association pattern, represented as a Maximum Association Graph (MAG), from the nucleus images of a population of cells. Our approach is based on an interesting integer linear programming formulation of the problem and utilizes inherent observations of the problem to yield optimal solutions. A two-stage technique is also introduced for producing near optimal approximations for large data sets.
