THE PROGNOSTIC-SIGNIFICANCE OF TRANSFORMING GROWTH-FACTORS IN HUMAN BREAST-CANCER
THE PROGNOSTIC-SIGNIFICANCE OF TRANSFORMING GROWTH-FACTORS IN HUMAN BREAST-CANCER
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DOI：
10.1038/bjc.1993.261
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发表时间：
1993-06-01
影响因子：
8.8
通讯作者：
COOMBES, RC
中科院分区：
文献类型：
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作者：
MURRAY, PA;BARRETTLEE, P;COOMBES, RC
转化生长因子 α (TGFα) 和转化生长因子 β-1 (TGF-β1) 在体外对乳腺癌细胞系具有生长调节作用，多项研究表明，肿瘤活检中的 TGFα 受体（表皮生长因子 (EGFR)）水平可预测复发和生存。我们检查了一系列原发性乳腺癌患者中 TGFα、TGF-β1 和 EGFR mRNA 表达的预后意义，中位随访期为 60 个月。在 167 名患者中，TGF-β1 的表达与淋巴结状态呈负相关（P = 0.065），但与 ER 状态、肿瘤大小或绝经状态无关。 TGF-β1 水平高的患者无病间隔期较长，80 个月时的生存概率显着较高，但总体无复发生存率并未增加。在 106 名患者中测量了 EGFR mRNA 表达，并与 ER 状态呈负相关（P=0.018）。 EGFR 水平并不能预测早期复发或生存。在 104 名患者中测量了 TGFα mRNA 水平，未发现肿瘤大小、淋巴结状态、Er 状态或临床结果存在相关性。
Transforming growth factor alpha (TGFalpha) and Transforming growth factor beta-1 (TGF-beta1) are growth regulatory for breast cancer cell lines in vitro and several studies have suggested that levels of the receptor for TGFalpha, the epidermal growth factor (EGFR) in tumour biopsies predict relapse and survival. We have examined the prognostic significance of TGFalpha, TGF-beta1 and EGFR mRNA expression in a series of patients with primary breast cancer with a median follow up period of 60 months. In 167 patients the expression of TGF-beta1 was inversely correlated with node status (P = 0.065) but not ER status, tumour size or menopausal status. Patients with high levels of TGF-beta1 had a longer disease free interval with a significantly longer probability of survival at 80 months although the overall relapse free survival was not increased. EGFR mRNA expression was measured in 106 patients and was inversely correlated with ER status (P=0.018). EGFR levels did not predict for early relapse or survival. TGFalpha mRNA levels were measured in 104 patients, no correlation was seen tumour size, node status, Er status, or clinical outcome.