The influence of smoking on semen quality, seminal microelements and Ca2+-ATPase activity among infertile and fertile men
The influence of smoking on semen quality, seminal microelements and Ca2+-ATPase activity among infertile and fertile men
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DOI：
10.1016/j.clinbiochem.2008.07.013
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发表时间：
2008-10-01
影响因子：
2.8
通讯作者：
Abduljabar, H. S.
中科院分区：
文献类型：
--
作者：
Kumosani, T. A.;Elshal, M. F.;Abduljabar, H. S.
目的：烟草吸烟现在在整个发展中国家迅速增加，是当前和未来世界健康的最大威胁之一。有几项研究讨论了吸烟对精液质量的影响，但确切的机制仍然没有定论。为了评估吸烟对沙特人精液质量的不利影响，对吸烟者和不吸烟者的不同精液参数水平进行了比较。患者和方法：共159份精液样本(61名吸烟者和98名不吸烟者)来自一家不育诊所进行常规不育症检查的男性，分为生育和不育两组，并根据标准精液分析(根据世卫组织指南)、金属含量(镁、结果：无论是生育组还是非吸烟组，吸烟者的镉含量均显著高于非吸烟者(2.9+/-0.4vs1.4+/-0.7；L分别为2.9+/-0.5和1.3+/-0.7亩·L-1。精浆中钙-三磷酸腺苷酶活性显著降低(21.5+/-2.8vs33.71+/-1.2；20.7+/-1.5vs35.07+/-2.9 mgmin(-1)mg(-1)蛋白，p
Objective: Tobacco smoking is now increasing rapidly throughout the developing world and is one of the biggest threats to current and future world health. Several studies have addressed the role of cigarette smoking on semen quality, but the exact mechanisms remain inconclusive. In order to evaluate the detrimental effects of smoking on semen quality among Saudi subjects, the levels of different seminal parameters in smokers were compared to non-smokers.Patients and methods: A total of 159 semen samples (61 smokers and 98 non-smokers) from men attending an infertility clinic for routine infertility workup, were sub-grouped into fertile or infertile and were compared based on standard semen analysis (according to WHO guidelines), content of metals (magnesium, zinc and cadmium) and plasma membrane Ca2+-ATPase activity of sperms.Results: Cadmium concentration was found significantly higher in smokers than in non-smokers either in fertile or infer-tile group (2.9 +/- 0.4 vs 1.4 +/- 0.7; 2.9 +/- 0.5 vs 1.3 +/- 0.7 mu g L-1; respectively). Together with this increase in seminal Cd a significant decrease in Ca2+-ATPase activity (21.5 +/- 2.8 vs 33.71 +/- 1.2; 20.7 +/- 1.5 vs 35.07 +/- 2.9 mmol min(-1) mg(-1) protein, p