Association of interleukin-1 receptor-associated kinase (IRAK1) gene polymorphisms (rs3027898, rs1059702) with systemic lupus erythematosus in a Chinese Han population
Association of interleukin-1 receptor-associated kinase (IRAK1) gene polymorphisms (rs3027898, rs1059702) with systemic lupus erythematosus in a Chinese Han population
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DOI：
10.1007/s00011-013-0607-2
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发表时间：
2013-06-01
影响因子：
6.7
通讯作者：
Ye, Dong-Qing
中科院分区：
文献类型：
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作者：
Zhai, Yu;Xu, Ke;Ye, Dong-Qing
本研究的目的是探讨中国汉族人群中白细胞介素1受体相关激酶（IRAK1）多态性（rs3027898、rs1059702）与系统性红斑狼疮（SLE）的关系。本研究共收集了667名SLE患者和667名健康对照者。多态性（rs3027898、rs1059702）的基因分型通过 7300 实时聚合酶链式反应系统上的 TaqMan 等位基因判别分析确定。通过卡方检验或Fisher精确检验进行统计分析。患者中rs3027898的C等位基因频率显着高于对照组（C与A：OR = 1.438，95％CI = 1.180-1.753，p < 0.001），并且在rs1059702中显示出类似的关联（A与G：OR = 1.383，95 % CI = 1.143-1.674，p = 0.001）。有趣的是，rs3027898 的 C 等位基因与口腔溃疡患者的风险降低相关。然而，IRAK1 rs1059702 多态性和临床表现没有检测到显着差异。我们的数据表明，IRAK1 基因 rs3027898 和 rs1059702 多态性与中国汉族人群的 SLE 相关。
The purpose of this study was to examine the association of interleukin-1 receptor-associated kinase (IRAK1) polymorphisms (rs3027898, rs1059702) with systemic lupus erythematosus (SLE) in a Chinese Han population.A total of 667 SLE patients and 667 healthy controls were collected in this study. The genotyping of polymorphisms (rs3027898, rs1059702) was determined by TaqMan allele discrimination assay on the 7300 real-time polymerase chain reaction system. The statistical analysis was conducted by chi square test or Fisher's exact test.The frequency of C allele for rs3027898 in patients was significantly higher than in controls (C versus A: OR = 1.438, 95 % CI = 1.180-1.753, p < 0.001), and a similar association was shown in rs1059702 (A versus G: OR = 1.383, 95 % CI = 1.143-1.674, p = 0.001). Interestingly, the C allele of rs3027898 was associated with a decreased risk for patients with oral ulcers. However, no significant difference was detected in IRAK1 rs1059702 polymorphism and the clinical manifestations.Our data demonstrate that the polymorphisms rs3027898 and rs1059702 of IRAK1 gene are associated with SLE in the Chinese Han population.