FORMULATION AND APPLICATION OF A NUMERICAL SCORING SYSTEM FOR ASSESSING HISTOLOGICAL ACTIVITY IN ASYMPTOMATIC CHRONIC ACTIVE HEPATITIS
FORMULATION AND APPLICATION OF A NUMERICAL SCORING SYSTEM FOR ASSESSING HISTOLOGICAL ACTIVITY IN ASYMPTOMATIC CHRONIC ACTIVE HEPATITIS
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DOI：
10.1002/hep.1840010511
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发表时间：
1981-01-01
期刊：
影响因子：
13.5
通讯作者：
WOLLMAN, J
中科院分区：
文献类型：
--
作者：
KNODELL, RG;ISHAK, KG;WOLLMAN, J
一种组织学活动指数已经被开发出来，它对无症状慢性活动性肝炎患者的肝活检标本产生一个数值评分。活组织检查分为四类：门静脉周围坏死、小叶内坏死、门静脉炎症和纤维化。根据代码，三名病理学家和三名肝病学家评估了来自五名无症状慢性活动性肝炎患者的14个肝活检标本。根据常规组织学描述判断的肝活检病变严重程度与组织学活动指数评分之间存在良好的相关性。在28个活检标本的重复评分中，只有2个出现了组织学活动指数评分的显著差异。该系统为肝组织学系列变化的统计分析提供了明确的终点，并在跟踪无症状慢性活动性肝炎的自然病史和治疗反应时，提供了一种替代传统病理描述的方法。
A Histology Activity Index has been developed which generates a numerical score for liver biopsy specimens obtained from patients with asymptomatic chronic active hepatitis. Biopsies are graded in four categories: periportal necrosis, intralobular necrosis, portal inflammation, and fibrosis. Under code, three pathologists and three hepatologists evaluated 14 liver biopsy specimens obtained from five patients with asymptomatic chronic active hepatitis. Good correlation was seen between severity of liver biopsy lesions as judged by conventional histological descriptions and Histology Activity Index scores. Significant differences in Histology Activity Index score occurred in only 2 of 28 duplicate scorings of biopsy specimens by two observers. This system provides definitive endpoints for statistical analysis of serial changes in liver histology and offers an alternative to the use of conventional pathological descriptions in following the natural history and treatment responses of asymptomatic chronic active hepatitis.