Ergot of rye - the first specific for migraine
Ergot of rye - the first specific for migraine
复制标题
DOI：
10.1016/j.jocn.2003.05.002
复制
发表时间：
2004-01-01
影响因子：
2
通讯作者：
Eadie, MJ
中科院分区：
文献类型：
--
作者：
Eadie, MJ
在过去的十年里，各种曲普坦衍生物已被公认为缓解偏头痛发作的最有效的可用药物。在此之前，在长达半个世纪的时间里，麦角胺是唯一可用于这一目的的“特效药”。1918年，斯托尔从麦角菌菌核的提取物中分离出了它，这种真菌生长在黑麦上，也生长在其他草上，程度较轻。到1925年，麦角胺开始被用于治疗偏头痛发作。然而，由于麦角胺在1862年首先在意大利被用于治疗偏头痛的麦角提取物中存在，然后由英国的爱德华·沃克斯(11868)和德国的阿尔伯特·尤伦堡(1883年)在他之后出现，因此这种药物实际上在麦角胺本身存在之前半个多世纪就开始用于治疗这种疾病。不幸的是，由于麦角胺的化学和药代动力学特性，黑麦麦角提取物不能产生一致的治疗结果，因此普遍接受治疗偏头痛的第一种特定物质的存在，必须等到纯麦角胺可供使用。(C)2003爱思唯尔有限公司。保留所有权利。
Over the past decade the various triptan derivatives have been accepted as the most effective available agents for relieving migraine attacks. Prior to that, for a period of half a century, ergotamine was the only 'specific' available for this purpose. In 1918, Stoll had isolated it from the various alkaloids present in extracts of the sclerotia of the fungus Claviceps purpurea (ergot), which grow on rye and, to a lesser extent, on other grasses. By 1925 ergotamine was beginning to be used to treat migraine attacks. However, as ergotamine was present in extracts of ergot, which had been used to treat migraine first, In Italy in 1862, and then by Edward Woakes (11868) in England, and after him by Albert Eulenburg in Germany (1883), the drug had actually come into unrecognised use for the disorder more than half a century before ergotamine itself was known to exist. Unfortunately, because of ergotamine's chemical and pharmacokinetic properties, extracts of ergot of rye were incapable of producing consistent therapeutic results, so that general acceptance that the first specific substance for migraine treatment existed had to wait until pure ergotamine was available for administration. (C) 2003 Elsevier Ltd. All rights reserved.