INCREASE OF DELETED MITOCHONDRIAL-DNA IN THE STRIATUM IN PARKINSONS-DISEASE AND SENESCENCE
INCREASE OF DELETED MITOCHONDRIAL-DNA IN THE STRIATUM IN PARKINSONS-DISEASE AND SENESCENCE
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DOI：
10.1016/0006-291x(90)90497-b
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发表时间：
1990-08-16
影响因子：
3.1
通讯作者：
OZAWA, T
中科院分区：
文献类型：
--
作者：
IKEBE, S;TANAKA, M;OZAWA, T
应用聚合酶链反应技术在帕金森病患者脑组织中检测到一个4, 977 bp缺失的线粒体DNA突变体。尽管在老年对照组的大脑中也能检测到缺失的mtDNA，但帕金森病患者纹状体中缺失的mtDNA与正常mtDNA的比例高于对照组。在帕金森病患者和老年对照组中，纹状体的比例高于大脑皮层。这些结果表明，与年龄相关的线粒体DNA缺失的积累在帕金森病纹状体加速，并建议删除有助于帕金森病的病理生理过程。
A mutant mitochondrial DNA (mtDNA) with a 4,977-bp deletion was detected in the parkinsonian brain by using the polymerase chain reaction. Although the deleted mtDNA was detectable even in the brain of aged controls, the proportion of deleted mtDNA to normal mtDNA in the striatum was higher in the parkinsonian patients than in the controls. In both the parkinsonian patients and the aged controls, the proportion was higher in the striatum than in the cerebral cortex. These results indicate that age-related accumulation of deleted mtDNA is accelerated in the parkinsonian striatum and suggest that the deletion contributes to pathophysiological processes underlying Parkinson''s disease.