Relationship between urinary concentrations of di(2-ethylhexyl) phthalate (DEHP) metabolites and reproductive hormones in polyvinyl chloride production workers
Relationship between urinary concentrations of di(2-ethylhexyl) phthalate (DEHP) metabolites and reproductive hormones in polyvinyl chloride production workers
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DOI：
10.1136/oemed-2014-102532
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发表时间：
2015-05-01
影响因子：
4.9
通讯作者：
Lee, Ching-Chang
中科院分区：
文献类型：
--
作者：
Fong, Jer-Pei;Lee, Fang-Jin;Lee, Ching-Chang
目的探讨聚氯乙烯(PVC)生产企业工人尿中邻苯二甲酸二(2-乙基己基)酯(DEHP)代谢产物与生殖激素的关系。暴露后，大部分DEHP被迅速代谢为邻苯二甲酸单(2-乙基己基)、邻苯二甲酸单(2-乙基-5-羟基己基)和邻苯二甲酸单(2-乙基-5-氧基己基)(MEOHP)，这可能与生殖激素干扰和睾丸毒性有关。一些研究报告称，塑料工人的尿邻苯二甲酸酯代谢物浓度明显高于普通人群。方法对82名男工进行横断面调查，测定其生殖激素的生物标志物和接触DEHP的情况。结果MEHP、MEOHP和MEHHP的尿肌酐调整(Mu g/g-Cre)的几何平均值分别为23.9、66.9和84.6。在调整了潜在混杂因素的多元回归模型中，尿DEHP代谢物浓度与雌二醇(E-2)呈显著正相关(p
Objectives We investigated the relationship between urinary metabolites of di(2-ethylhexyl) phthalate (DEHP) and reproductive hormones in workers of polyvinyl chloride (PVC) production plants. After exposure, most of the DEHP is rapidly metabolised to mono(2-ethylhexyl) phthalate (MEHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP), which may be associated with reproductive hormone interruption and testicular toxicity. Some studies report that urinary concentrations of phthalate metabolites for plastics workers are significantly higher than for the general population. However, little is known about the disruption of reproductive hormones for DEHP exposure workers.Methods This cross-sectional study of 82 male workers measured the biomarkers for their reproductive hormones and their exposure to DEHP. Relationships between urinary concentrations of DEHP metabolites were estimated using multivariate linear regression and quartile analysis models.Results The geometric means of urinary creatinine-adjusted (mu g/g-Cre) concentrations of MEHP, MEOHP and MEHHP during the post-shift period were 23.9, 66.9 and 84.6, respectively. In multiple regression models adjusted for potential confounders, there were significant positive associations between urinary concentrations of DEHP metabolites and estradiol (E-2) (p