An efficient method for chlorination of alcohols using PPh3/Cl3CCONH2
An efficient method for chlorination of alcohols using PPh3/Cl3CCONH2
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DOI：
10.1016/j.tetlet.2006.07.060
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发表时间：
2006-09-18
影响因子：
1.8
通讯作者：
Chavasiri, Warinthorn
中科院分区：
文献类型：
--
作者：
Pluempanupat, Wanchai;Chavasiri, Warinthorn
提出了一种利用PPh3/Cl3CCONH2进行醇类氯化反应的简便新方法。在温和的条件下，短的反应时间内，各种醇都能以较高的收率顺利地转化为相应的烷基氯化物。揭示了由R-(-)-2-辛醇衍生的类似氯烷基的构型反转机理。(c) 2006 Elsevier Ltd.版权所有。
A new and convenient method for the chlorination of alcohols utilizing PPh3/Cl3CCONH2 is addressed. Various alcohols could smoothly be converted into their corresponding alkyl chlorides in high yield under mild conditions with short reaction times. A mechanism is disclosed with the evidence of inversion of configuration of the analogous alkyl chloride derived from R-(-)-2-octanol. (c) 2006 Elsevier Ltd. All rights reserved.