Features of polycystic ovary syndrome (PCOS) in women with functional hypothalamic amenorrhea (FHA) may be reversible with recovery of menstrual function
Features of polycystic ovary syndrome (PCOS) in women with functional hypothalamic amenorrhea (FHA) may be reversible with recovery of menstrual function
复制标题
DOI：
10.1080/09513590.2017.1395842
复制
发表时间：
2018-01-01
影响因子：
2
通讯作者：
Lobo, Roger A.
中科院分区：
文献类型：
--
作者：
Carmina, Enrico;Fruzzetti, Franca;Lobo, Roger A.
目的：由于多囊卵巢综合征（PCOS）的特点已被发现是普遍存在于女性功能性下丘脑闭经（FHA），我们希望确定发生了什么，月经功能恢复后，这些功能在FHADesign：前瞻性队列研究。方法：对28例FHA患者和30例年龄匹配的排卵对照者进行研究。我们测量了血清雌二醇、LH、FSH、睾酮、DHEAS、抗苗勒管激素（AMH）、体重指数和经阴道超声检查的卵巢形态。结果：基线时，28名妇女中有12名（43%）AMH升高（>4.7ng/mL），与其他16名AMH正常的妇女相比，睾酮水平较高，卵巢较大。月经功能恢复1年后，AMH升高的12例妇女血清AMH、睾酮和卵巢大小下降，LH和雌二醇升高。在一年内，只有一个高AMH组的12名妇女开发的PCOS.Conclusions的临床特征：在大多数女性FHA有PCOS样功能，这些功能可能是由于下丘脑状态，似乎是可逆的。很少有女性在康复后会发展为临床PCOS。
Objective: Since features of polycystic ovary syndrome (PCOS) have been found to be prevalent in women with functional hypothalamic amenorrhea (FHA), we wished to determine what happens to these features after recovery of menstrual function in FHADesign: Prospective cohort study. Twenty-eight women with FHA and 30 age-matched ovulatory controls were studied.Methods: Twenty-eight women with FHA and 30 age-matched ovulatory controls were studied. We measured serum estradiol, LH, FSH, testosterone, DHEAS, anti-Mullerian hormone (AMH), body mass index, and ovarian morphology on transvaginal ultrasound.Results: At baseline, 12 of the 28 women (43%) had increased AMH (>4.7ng/mL), and higher testosterone and larger ovaries compared to the other 16 women with normal AMH. One year after recovery of menstrual function, in the 12 women with increased AMH, serum AMH, testosterone and ovarian size decreased, while LH and estradiol increased. At one year, only one of the 12 women in the high AMH group developed clinical features of PCOS.Conclusions: In the majority of women with FHA who have PCOS-like features, these features may be due to the hypothalamic state and appear to be reversible. Few women may develop clinical PCOS after recovery.