Eosinophils, smoking, and lung function. An epidemiologic survey among 912 working men.
Eosinophils, smoking, and lung function. An epidemiologic survey among 912 working men.
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嗜酸性粒细胞、吸烟和肺功能。
DOI：
10.1164/arrd.1986.134.6.1172
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
J. Lellouch
中科院分区：
文献类型：
--
作者：
F. Kauffmann;F. Neukirch;M. Korobaeff;M. Marne;J. Claude;J. Lellouch
在巴黎地区的912名男性工作人群中研究了嗜酸性粒细胞增多症与吸烟习惯和基线肺功能测量的关系。嗜酸性粒细胞的绝对数量显着相关的哮喘和湿疹的历史，在儿童时期，以及目前的烟草消费，而嗜酸性粒细胞的百分比仅与哮喘和湿疹的发生。经吸烟校正后的第一秒用力呼气量与哮喘、有喘息史者检查当天是否患感冒以及嗜酸性粒细胞百分比显著相关。FEV和嗜酸性粒细胞之间的关联仅限于从不吸烟者。在检查当天无哮喘、湿疹、喘息或普通感冒病史的从不吸烟者中，嗜酸性粒细胞百分比和计数与FEV水平显著相关;嗜酸性粒细胞百分比解释FEV方差的4.4%。这些结果表明，嗜酸性粒细胞增多症可能是一个危险因素慢性气流限制成人非吸烟者。
The relationship of eosinophilia with smoking habits and with baseline lung function measurements has been studied in a working population of 912 men in the Paris area. Absolute numbers of eosinophils were related significantly to a history of asthma and eczema in childhood as well as to current tobacco consumption, whereas the percentage of eosinophils was related only to the occurrence of asthma and eczema. Forced expiratory volume in one second adjusted for smoking was significantly related to asthma, the presence of a common cold on the day of examination among those with a history of wheezing, and the percentage of eosinophils. The association between FEV and eosinophils was restricted to never smokers. Among never smokers without a history of asthma, eczema, wheezing, or a common cold on the day of examination, eosinophil percentages and counts were significantly associated with the level of FEV; eosinophil percentages explained 4.4% of the variance of FEV. These results suggest that eosinophilia might be a risk factor for chronic air-flow limitation among adult nonsmokers.