Cortical morphometry and structural connectivity relate to executive function and estradiol level in healthy adolescents.
Cortical morphometry and structural connectivity relate to executive function and estradiol level in healthy adolescents.
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皮质形态测量和结构连接与健康青少年的执行功能和雌二醇水平有关。
DOI：
10.1002/brb3.1413
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发表时间：
2019
影响因子：
3.1
通讯作者：
Depue,BrendanE
中科院分区：
文献类型：
--
作者：
Stoica,Teodora;Knight,LindsayKathleen;Naaz,Farah;Ramic,Melina;Depue,BrendanE
情绪和行为控制是维持稳定的目标驱动行为所必需的自我调节过程。研究表明，这些执行功能（EF）过程的差异与大脑的形态学特征和白色物质（WM）的差异有关。此外，性激素水平可能会调节电路在大脑中重要的认知function.MethodsWe的目的是调查结构神经相关的EF行为在灰质（GM）和WM，同时考虑到雌二醇水平，在青少年人群。本研究从美国国立卫生研究院儿科数据库（NIHPD）获得了神经影像学、行为学和生理学数据。我们使用父母管理的行为监测工具分析了皮质形态测量和结构连接之间的关系（N= 55）。结果执行功能行为和雌二醇水平与右后背外侧前额叶皮层（pDLPFC）和初级运动皮层（PMC）的皮质形态计量学双向相关，以及镊子大、小部分各向异性（FA）。最后，EF行为和雌二醇水平的相互作用与右PMC的体积减少有关，并与右额枕下束（iFOF）的FA改变有关。结论该研究提供了证据，EF行为和雌二醇水平之间的关系与双向GM和WM差异有关，这意味着雌二醇水平对EF行为潜在的假定结构区域有影响。这些发现代表了青春期EF行为和荷尔蒙对大脑结构影响之间的关键联系。
IntroductionEmotional and behavioral control is necessary self‐regulatory processes to maintain stable goal‐driven behavior. Studies indicate that variance in these executive function (EF) processes is related to morphological features of the brain and white matter (WM) differences. Furthermore, sex hormone level may modulate circuits in the brain important for cognitive function.MethodsWe aimed to investigate the structural neural correlates of EF behavior in gray matter (GM) and WM while taking into account estradiol level, in an adolescent population. The present study obtained neuroimaging behavioral and physiological data from the National Institute of Health's Pediatric Database (NIHPD). We analyzed the relationship between cortical morphometry and structural connectivity (N= 55), using a parent‐administered behavioral monitoring instrument (Behavior Rating Inventory of Executive Function—BRIEF), estradiol level, as well as their interaction.ResultsExecutive function behavior and estradiol level related to bidirectional associations with cortical morphometry in the right posterior dorsolateral prefrontal cortex (pDLPFC) and primary motor cortex (PMC), as well as fractional anisotropy (FA) in the forceps major and minor. Lastly, the interaction of EF behavior and estradiol level related to decreased volume in the right PMC and was linked to altered FA in the right inferior fronto‐occipital fasciculus (iFOF).ConclusionsThe study provides evidence that the relationship between EF behavior and estradiol level related to bidirectional GM and WM differences, implying estradiol level has an influence on the putative structural regions underlying EF behavior. The findings represent a crucial link between EF behavior and hormonal influence on brain structure in adolescence.