Transmission of influenza A in families
Transmission of influenza A in families
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DOI：
10.1097/inf.0b013e3180616cfb
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发表时间：
2007-07-01
影响因子：
3.6
通讯作者：
Booy, Robert
中科院分区：
文献类型：
--
作者：
Teo, Stephen S. S.;Ellis, Joanna S.;Booy, Robert
我们进行了一项前瞻性的巢式研究，使用核苷酸测序来检查流感阳性呼吸道样本中的血凝素和神经氨酸酶基因的遗传同源性。来自3个家族的甲型流感H3N2病毒具有相同的家族特异性HA1核苷酸序列。这些家庭之间的序列是遗传异质性。通过流感神经氨酸酶基因的测序来区分第4个家族。
We conducted a prospective, nested study using nucleotide sequencing to examine influenza positive respiratory samples in families for genetic homology in the hemagglutinin and neuraminidase genes. Influenza A H3N2 viruses from 3 families had identical, family specific, HA1 nucleotide sequences. Sequences among these families were genetically heterogeneous. A 4th family was distinguished by sequencing of the influenza neuraminidase gene.