Obesity is associated with increased risk of allergy in Vietnamese adolescents
Obesity is associated with increased risk of allergy in Vietnamese adolescents
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DOI：
10.1038/sj.ejcn.1602120
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发表时间：
2005-04-01
影响因子：
4.7
通讯作者：
Yamamoto, S
中科院分区：
文献类型：
--
作者：
Irei, AV;Takahashi, K;Yamamoto, S
背景：过敏性疾病的患病率在过去几十年中随着肥胖个体数量的增加而显著增加。肥胖与变态反应性疾病的研究结果存在争议，大多数研究与哮喘及哮喘样症状有关。目的：本研究评价了几种肥胖指标与支气管哮喘、过敏性鼻结膜炎、特应性皮炎和食物过敏等变态反应性疾病患病率的关系。设计：横断面研究。结果：在总共1185名12至17岁的青少年（49.3%为男孩）中，19.3%报告了医生诊断的过敏性疾病，35.3%报告了未诊断的过敏症状。Logistic回归分析显示，儿童过敏的风险较高，（OR=2.02，CI：1.12-3.64）和高（OR=2.40，CI：1.25-4.61）与低社会经济地位相比，在报告附近工业排放的受试者中，（OR=2.19，CI：1.40-3.41），父母有过敏史的青少年（OR=1.92，CI：1.26-2.92）。体质指数（BMI）和体脂百分比（%BF）与过敏显著相关（BMI OR=1.16，CI：1.01-1.34; %BF OR=1.03，CI：1.01-1.06）。在控制了社会经济地位、工业排放和父母过敏史后，只有%BF仍具有统计学显著性（OR=1.03，CI：1.01-1.06）。在我们的研究人群中，食物过敏与肥胖无关，当从分析中排除有食物过敏的青少年时，BMI标准差每增加，过敏的几率增加28（OR=1.28，CI：1.05-1.57），体脂百分比每增加1个单位增加5%结论：在本研究人群中，超重与过敏风险增加有关。我们的研究结果指出了超重和鼻结膜炎之间的联系，而不是食物过敏。未观察到与其他过敏性疾病相关。
Background: The prevalence of allergic diseases has remarkably increased in the last decades in tandem with the number of obese individuals. Results of studies on obesity and allergic diseases are controversial, and most of them are related to asthma and asthma-like symptoms.Objective: In our study, we evaluated the association of several obesity indices and the prevalence of allergic diseases, including bronchial asthma, allergic rhino-conjunctivitis, atopic dermatitis and food allergy.Design: Cross-sectional study.Results: From a total of 1185 adolescents (49.3% boys) aged 12 to 17y old, 19.3% reported a physician-diagnosed allergic disease, and 35.3% reported undiagnosed allergic symptoms. Logistic regression analysis revealed a higher risk of allergy in children of middle (OR=2.02, CI: 1.12-3.64) and high (OR=2.40, CI: 1.25-4.61) compared to low socioeconomic status, in subjects reporting industrial emissions in the neighborhood (OR=2.19, CI: 1.40-3.41), and in adolescents with parental history of allergy (OR=1.92, CI: 1.26-2.92). Body mass index (BMI) and percentage of body fat (%BF) were significantly related to allergy (OR=1.16, CI: 1.01-1.34 for BMI; OR=1.03, CI: 1.01-1.06 for %BF). After controlling for socioeconomic status, industrial emissions and parental history of allergy, only %BF remained statistically significant (OR=1.03, CI: 1.01-1.06). Food allergy was not related to obesity in our study population, and when adolescents with food allergy were excluded from the analysis, the odds of having allergy increased 28% with each increase in SD of BMI (OR=1.28, CI: 1.05-1.57) and 5% for each unit increase in the percentage of body fat (OR=1.05, CI: 1.01-1.08).Conclusion: In conclusion, being overweight was associated with an increased risk of allergy in our study population. Our results point towards an association between being overweight and rhino-conjunctivitis, but not food allergy. No association was observed with other allergic diseases.