1H MR Spectroscopy in Patients with Metastatic Brain Tumors: A Multicenter Study
1H MR Spectroscopy in Patients with Metastatic Brain Tumors: A Multicenter Study
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转移性脑肿瘤患者的 1H 磁共振波谱检查：一项多中心研究
DOI：
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发表时间：
1995
影响因子：
3.3
通讯作者：
M. Oudkerk
中科院分区：
文献类型：
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作者：
P. Sijens;M. Knopp;A. Brunetti;K. Wicklow;B. Alfano;P. Bachert;J. Sanders;A. Stillman;H. Kett;R. Sauter;M. Oudkerk
在一项涉及6个临床MR中心的合作研究中，使用定位的1H磁共振波谱来表征未经治疗的转移性脑肿瘤(40例，45个病灶)。采用单体素双自旋回波磁共振成像技术，采用化学位移选择性成像(CHESS)脉冲抑制水，TE=135ms，用单体素双自旋回波MRS检查脑转移灶占50%以上的立方体体积(3.4或8cm3)。13例乳腺癌、11例肺癌和10例黑色素瘤脑转移瘤的胆碱(Cho)、肌酸(Cr)和N-乙酰天冬氨酸(NAA)水平相似。转移灶NAA/CHO信号强度比在枕叶为2.68±0.56(SD)，尾状核为1.94±0.63(P<；0.0001)。1H磁共振波谱虽然不适合识别转移的原发肿瘤，但可以作为一种临床试验，排除转移性肿瘤是孤立性局灶性脑疾病的原因，而目前的成像方法难以诊断。
In a cooperative study involving six clinical MR centers, localized 1H MR spectroscopy was used to characterize untreated metastatic brain tumors (40 cases, 45 lesions). Cubic volumes (3.4 or 8 cm3) filled for more than 50% by metastatic brain tissue were examined by single‐voxel double spin echo MRS, by using chemical shift selective imaging (CHESS) pulses for water suppression and TE = 135 ms. Choline (Cho), creatine (Cr) and N‐acetyl aspartate (NAA) levels in brain metastases of mammary carcinoma (n = 13), lung cancer (n = 11) and melanoma (n = 10) were similar. Metastasis NAA/Cho signal intensity ratio varied between 0.00 and 1.17, compared with 2.68 ± 0.56 (SD) in lobus occipitalis and 1.94 ± 0.63 in corpus nuclei caudati region (P < 0.0001, both). 1H MR spectroscopy, although not suited to recognize the primary tumor of metastases, could serve as a clinical test for excluding (metastatic) tumor as cause of solitary focal brain disorders that are hard to diagnose with current imaging methods.