Structure of the human myelin/oligodendrocyte glycoprotein gene and multiple alternative spliced isoforms.
Structure of the human myelin/oligodendrocyte glycoprotein gene and multiple alternative spliced isoforms.
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人髓磷脂/少突胶质细胞糖蛋白基因的结构和多种选择性剪接亚型。
DOI：
10.1006/geno.1995.9995
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发表时间：
1995
期刊：
影响因子：
4.4
通讯作者：
A. Dautigny
中科院分区：
文献类型：
--
作者：
D. Pham‐Dinh;B. Della Gaspera;N. Kerlero de Rosbo;A. Dautigny
髓磷脂/少突胶质细胞糖蛋白 (MOG) 是中枢神经系统的一种特定成分，位于成熟髓磷脂的最外层，是免疫球蛋白超家族的成员。我们在这里报告了人类 MOG 基因的组织，该基因跨度约为 17 kb，以及六种 MOG mRNA 剪接变体的特征。人类 MOG 基因的内含子/外显子结构证实了剪接模式，支持了 mRNA 同工型可能通过单个基因的选择性剪接产生的假设。另外八个外显子编码为主要。 MOG 同种型，人类 MOG 基因在 3' 区域还包含一个先前未知的可变剪接编码外显子 VIA。外显子 VIII 的两个受体剪接位点的替代利用可以产生两个不同的 C 末端。这里提供的核苷酸序列可能是进一步研究 MOG 基因在遗传性神经系统疾病中可能参与的有用工具。
Myelin/oligodendrocyte glycoprotein (MOG), a specific component of the central nervous system localized on the outermost lamellae of mature myelin, is a member of the immunoglobulin superfamily. We report here the organization of the human MOG gene, which spans approximately 17 kb, and the characterization of six MOG mRNA splicing variants. The intron/exon structure of the human MOG gene confirmed the splicing pattern, supporting the hypothesis that mRNA isoforms could arise by alternative splicing of a single gene. In addition to the eight exons coding for the major. MOG isoform, the human MOG gene also contains, in the 3' region, a previously unknown alternatively spliced coding exon, VIA. Alternative utilization of two acceptor splicing sites for exon VIII could produce two different C-termini. The nucleotide sequences presented here may be a useful tool to study further possible involvement of the MOG gene in hereditary neurological disorders.