Suppressive effects of diesel exhaust particles on cytokine release from human and murine alveolar macrophages
Suppressive effects of diesel exhaust particles on cytokine release from human and murine alveolar macrophages
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DOI：
10.1080/01902140303770
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发表时间：
2003-04-01
影响因子：
1.7
通讯作者：
Yamaguchi, K
中科院分区：
文献类型：
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作者：
Amakawa, K;Terashima, T;Yamaguchi, K
流行病学研究表明，呼吸系统疾病的住院人数增加与小于10微米的高浓度颗粒物（PM10）有关。柴油机排气颗粒物（DEP）是PM10的重要组成部分。本研究旨在检测DEP对肺泡巨噬细胞（AM）释放细胞因子的影响。将人和鼠AM暴露于DEP 24小时，并通过酶联免疫吸附测定（ELISA）测量上清液中肿瘤坏死因子（达特）-α、白细胞介素（IL）-6和IL-8的浓度。DEP（10 μ g/mL）抑制海洋AM自发释放TNF-α和IL-6（P
Epidemiological studies have shown an increase in the number of hospital admissions for respiratory diseases in association with high concentrations of particulate matter smaller than 10 mum (PM10). Diesel exhaust particles (DEP) are important components of PM10. This study was designed to test the effect of DEP on the release of cytokines from alveolar macrophages (AMs). Human and murine AMs were exposed to DEP for 24 hours, and the concentrations of tumor necrosis factor (TAT)-alpha, interleukin (IL)-6, and IL-8 were measured in the supernatants by enzyme-linked immunosorbent assay (ELISA). DEP (10 mug/mL) suppressed the spontaneous release of TNF-alpha and IL-6 from marine AMs (P