Investigation of miRNA- and lncRNA-mediated competing endogenous RNA network in cholangiocarcinoma
Investigation of miRNA- and lncRNA-mediated competing endogenous RNA network in cholangiocarcinoma
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DOI：
10.3892/ol.2019.10852
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发表时间：
2019-11-01
期刊：
影响因子：
2.9
通讯作者：
Fa, Xianen
中科院分区：
文献类型：
--
作者：
He, Yanxin;Liu, Chao;Fa, Xianen
Cholangiocarcinoma (CCA) is a biliary malignancy which is prone to lymphatic metastasis and has a high mortality rate. This disease lacks effective therapeutic targets and prognostic molecular biomarkers. The aim of the current study was to investigate differentially expressed genes and elucidate their association with CCA and the underlying mechanisms of action. mRNAs, long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) obtained from 36 CCA samples and nine normal samples from The Cancer Genome Atlas were integrated. Subsequently, 1,095 differentially expressed (DE) mRNAs and 75 DE miRNAs were identified using a threshold of vertical bar log2 fold change vertical bar>2 and an adjusted P
