Filarial/human immunodeficiency virus coinfection in urban southern India
Filarial/human immunodeficiency virus coinfection in urban southern India
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DOI：
10.4269/ajtmh.2008.79.558
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发表时间：
2008-10-01
影响因子：
3.3
通讯作者：
Nutman, Thomas B.
中科院分区：
文献类型：
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作者：
Talaat, Kawsar R.;Kumarasamy, Nagalingeswaran;Nutman, Thomas B.
人类免疫缺陷病毒（HIV）的病程常常因现有或新获得的合并感染而改变。治疗或预防这些伴随感染通常可以改善艾滋病毒感染者的生活质量和寿命。蠕虫感染对艾滋病毒感染的影响尚不清楚。然而，在蠕虫感染常见的地区，艾滋病毒往往是最成问题的。在广泛分发消除淋巴丝虫病的药物之前，我们在相隔四年的两个时间点评估了印度钦奈 HIV 阳性患者中活动性班氏丝虫病感染的患病率。我们发现，HIV阳性者中班克罗夫丝虫感染的总体患病率为5-9.5%，并且HIV阳性和HIV阴性丝虫感染者之间的循环丝虫抗原水平没有数量差异。
The disease course of human immunodeficiency virus (HIV) is often altered by existing or newly acquired coinfections. Treatment or prevention of these concomitant infections often improves the quality and duration of life of HIV-infected persons. The impact of helminth infections on infections with HIV is less clear. However, HIV is frequently most problematic in areas where helminth infections are common. In advance of the widespread distribution of drugs for elimination of lymphatic filariasis, we assessed the prevalence of active Wuchereria bancrofti infection among HIV-positive patients in Chennai, India at two time points separated by four years. We found that the overall prevalence of W. bancrofti infections among HIV-positive persons was 5-9.5%, and there were no quantitative differences in circulating filarial antigen levels between HIV-positive and HIV-negative filarial-infected patients.