Changes in sulfated mucopolysaccharide composition of mammalian tissues during growth and in cancer tissues.
Changes in sulfated mucopolysaccharide composition of mammalian tissues during growth and in cancer tissues.
复制标题
哺乳动物组织在生长过程中和癌症组织中硫酸化粘多糖组成的变化。
DOI：
10.1016/0304-4165(77)90093-9
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
O. G. Filho
中科院分区：
文献类型：
--
作者：
L. O. Sampaio;C. Dietrich;O. G. Filho
本文报道了硫酸化粘多糖在生长过程中不同组织中的分布以及在肿瘤组织中的分布。结果表明，1日龄大鼠和兔的大部分组织含有硫酸软骨素A/C、硫酸软骨素B和硫酸肝素，而成年动物的硫酸软骨素A/C减少或消失。在大多数组织中还观察到硫酸软骨素B和硫酸肝素的相对比例的变化。在大鼠中，这些变化发生在宫外发育的前25天。在不同来源的人肿瘤组织中，硫酸软骨素A/C值与正常组织相比明显升高。在所分析的大多数肿瘤中，也观察到硫酸软骨素B和硫酸肝素的相对比例的变化。根据本研究结果，讨论了硫酸软骨素A/C在细胞分裂中的可能作用。
The distribution of sulfated mucopolysaccharides in different tissues during growth and in cancer tissues is reported. It is shown that most of the tissues of 1 day-old rats and rabbits contain chondroitin sulfate A/C, chonroitin sulfate B and heparan sulfate in about the same proportions, whereas in adult animals chondroitin sulfate A/C decreases in concentration or disappears. Changes in the relative proportions of chondroitin sulfate B and heparan sulfate were also observed in most of the tissues. In rats, these changes occur in the first 25 days of extrauterine development. A great increase of chondoitin sulfate A/C was observed in human tumors of different origins when compared with the normal adjacent tissues. Changes in the relative proportions of chondroitin sulfate B and heparan sulfate were also observed in most of the tumors analysed. The possible role of chondroitin sulfate A/C in cell division is discussed in view of the present findings.