Dendrite self-avoidance is controlled by Dscam
Dendrite self-avoidance is controlled by Dscam
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DOI：
10.1016/j.cell.2007.04.013
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发表时间：
2007-05-04
期刊：
影响因子：
64.5
通讯作者：
Grueber, Wesley B.
中科院分区：
文献类型：
--
作者：
Matthews, Benjamin J.;Kim, Michelle E.;Grueber, Wesley B.
树突区分姐妹枝和其他细胞的枝。自我认同往往会导致排斥，这一过程被称为"自我回避"。“在这里，我们证明了果蝇da感觉神经元中的树突自我回避需要由Dscam基因座编码的细胞识别分子。通过选择性剪接，Dscam编码免疫球蛋白超家族的大量细胞表面蛋白。我们表明，相同的Dscam亚型之间的相互作用的细胞表面上的自我识别的基础，而胞质尾将这种识别树突排斥。表达相同同种型的姐妹树突参与同种排斥。相比之下，Dscam多样性确保共享相同感受野的树突之间不适当的排斥相互作用不会发生。Dscam介导的细胞相互作用的选择性可能在发育中的果蝇神经系统中非常重要，在神经回路的构建过程中，细胞的过程必须区分自我和非自我。
Dendrites distinguish between sister branches and those of other cells. Self-recognition can often lead to repulsion, a process termed "self-avoidance." Here we demonstrate that dendrite self-avoidance in Drosophila da sensory neurons requires cell-recognition molecules encoded by the Dscam locus. By alternative splicing, Dscam encodes a vast number of cell-surface proteins of the immunoglobulin superfamily. We demonstrate that interactions between identical Dscam isoforms on the cell surface underlie self-recognition, while the cytoplasmic tail converts this recognition to dendrite repulsion. Sister dendrites expressing the same isoforms engage in homophilic repulsion. By contrast, Dscam diversity ensures that inappropriate repulsive interactions between dendrites sharing the same receptive field do not occur. The selectivity of Dscam-mediated cell interactions is likely to be widely important in the developing fly nervous system, where processes of cells must distinguish between self and nonself during the construction of neural circuits.