Mortality from cancers of major sites in female radium dial workers.
Mortality from cancers of major sites in female radium dial workers.
复制标题
女性镭表盘工人主要部位癌症死亡率。
DOI：
10.1002/ajim.4700050604
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发表时间：
1984
影响因子：
3.5
通讯作者：
Andrew F. Stehney
中科院分区：
文献类型：
--
作者：
J. Stebbings;H. Lucas;Andrew F. Stehney
现在，除了骨肉瘤和长期以来被认为是由镭引起的头部癌症外，这些女性刻度盘工作人员已经经历了大量的癌症死亡。在1,285名1930年以前的Dial工人中，研究了镉暴露与胃癌、胰腺癌、结肠癌、直肠癌、肝癌、肺癌、乳腺癌、宫颈癌和子宫体癌以及白血病死亡率的关系。死亡率与美国白人女性的预期死亡率进行了比较，对当地死亡率进行了调整和不调整，并与1930年至1949年接触过的拨号员的死亡率进行了比较。本文报告了自1955年以来共测量693例人体镉含量的病例，研究了肿瘤与全身镉摄入量和工龄的剂量-反应关系。肝癌、胰腺癌、子宫颈癌和子宫癌明显与暴露于镭无关。其他消化道癌症似乎是间接的，如果有的话，与在镭设备中工作有关。肺癌需要进一步调查；Dial工作人员的吸入暴露被审查。对乳腺癌数据的分析发现了几个与先前提出的与镭暴露有关的因果关系不一致的观察结果。多发性骨髓瘤也被复习。多发性骨髓瘤导致的死亡风险增加了三倍，但与工作年限(外部伽马辐射的替代物)的关系比与镭摄入量的关系更密切。
The female radium dial workers have now experienced significant mortality from cancers other than the bone sarcomas and head carcinomas long known to be radium induced. The relationships of radium exposure to mortality from cancers of the stomach, pancreas, colon, rectum, liver, lung, breast, cervix, and corpus uteri, and from leukemia were studied in 1,285 pre-1930 dial workers. Mortality was compared with that expected from rates for US white females, with and without adjustment for local area mortality rates, and with mortality in dial workers exposed from 1930 to 1949. For the 693 cases whose body content of radium has been measured since 1955, dose-response relationships of cancer to systemic intake of radium and duration of employment were examined. Liver, pancreatic, cervical, and uterine cancers were clearly unrelated to radium exposure. Other cancers of the digestive tract appeared to be indirectly, if at all, associated with work in radium facilities. Lung cancer requires further investigation; inhalation exposures of the dial workers were reviewed. Analyses of the breast cancer data uncovered several observations inconsistent with the previously suggested causal association with radium exposure. Multiple myeloma was also reviewed. A threefold excess risk of death due to multiple myeloma has occurred, but is more closely correlated with duration of employment (a surrogate for external gamma radiation) than with radium intake.
明尼苏达州奥姆斯特德县多发性骨髓瘤的发病率和长期趋势：1965-77 年。
DOI：
--
发表时间：
1981
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Linos,A;Kyle,RA;O'Fallon,WM;Kurland,LT
通讯作者：
Kurland,LT