Human inferior colliculus activity relates to individual differences in spoken language learning
Human inferior colliculus activity relates to individual differences in spoken language learning
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DOI：
10.1152/jn.00923.2011
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发表时间：
2012-03-01
影响因子：
2.5
通讯作者：
Wong, Patrick C. M.
中科院分区：
文献类型：
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作者：
Chandrasekaran, Bharath;Kraus, Nina;Wong, Patrick C. M.
作者：Chandrasekaran B，Kraus N，Wong PC.人类下丘活动与口语学习的个体差异有关。《神经生理学杂志》107：第1325-1336,2012。2011年11月30日首次出版；doi：10.1152/jn.00923.2011。-学习外语单词的一个挑战是对非母语音素进行编码，这一过程通常被归因于大脑皮层电路。使用多模式成像方法[功能磁共振成像-适应(fMRI-A)和听觉脑干反应(ABR)]，我们检查了在学习成功地使用非母语基音模式辨别美国英语成年人的学习中，下丘(IC)的基音编码与个体差异性相关的预训练程度。FMRI-A指数定位于IC的音调表征效率，而ABR则以毫秒级的精度量化与中脑音调相关的活动。与神经“锐化”模型一致，我们发现有效的IC基音模式表征(由fMRI索引)与更好的基音模式神经表征(由ABR索引)相关，从而在语音到意义训练后更成功地学习单词。我们的结果确定了IC在语音-声音表示中的关键作用，这与IC在其他动物模型中表示交流信号的既定角色是一致的。
Chandrasekaran B, Kraus N, Wong PC. Human inferior colliculus activity relates to individual differences in spoken language learning. J Neurophysiol 107: 1325-1336, 2012. First published November 30, 2011; doi:10.1152/jn.00923.2011.-A challenge to learning words of a foreign language is encoding nonnative phonemes, a process typically attributed to cortical circuitry. Using multimodal imaging methods [functional magnetic resonance imaging-adaptation (fMRI-A) and auditory brain stem responses (ABR)], we examined the extent to which pretraining pitch encoding in the inferior colliculus (IC), a primary midbrain structure, related to individual variability in learning to successfully use nonnative pitch patterns to distinguish words in American English-speaking adults. fMRI-A indexed the efficiency of pitch representation localized to the IC, whereas ABR quantified midbrain pitch-related activity with millisecond precision. In line with neural "sharpening" models, we found that efficient IC pitch pattern representation (indexed by fMRI) related to superior neural representation of pitch patterns (indexed by ABR), and consequently more successful word learning following sound-to-meaning training. Our results establish a critical role for the IC in speech-sound representation, consistent with the established role for the IC in the representation of communication signals in other animal models.