Seroprevalence of Kaposi's sarcoma-associated herpesvirus among men who have sex with men in Japan
Seroprevalence of Kaposi's sarcoma-associated herpesvirus among men who have sex with men in Japan
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日本男男性行为者中卡波西肉瘤相关疱疹病毒的血清阳性率
DOI：
10.1002/jmv.23558
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发表时间：
2013
影响因子：
12.7
通讯作者：
Yasuoka A
中科院分区：
文献类型：
--
作者：
Katano H;Yokomaku Y;Fukumoto H;Kanno T;Nakayama T;Shingae A;Sugiura W;Ichikawa S;Yasuoka A
卡波西肉瘤相关疱疹病毒（KSHV）是卡波西肉瘤的病原体，常在获得性免疫缺陷综合征患者中引起恶性肿瘤。在美国和欧洲，KSHV感染在男男性行为者中很常见。然而，在日本，KSHV在男男性行为者中的血清阳性率尚不清楚。在本研究中，使用混合抗原（KSHV编码的K8. 1，开放阅读框59、65和73蛋白）酶联免疫吸附试验和免疫荧光试验，在230名男男性行为者和400名年龄和居住地区匹配的男性（对照）中调查了KSHV的血清阳性率。在与男性发生性关系的日本男性中，血清学检测显示，27名（11.7%）KSHV血清阳性;对照组中的20名（5%）男性也是KSHV血清阳性。男男性行为者KSHV阳性率显著高于对照组（OR = 2.52，95%可信区间= 1.38- 4.62，P = 0.0019，卡方检验）。人类免疫缺陷病毒、梅毒螺旋体、B和C型肝炎病毒感染与KSHV感染无关。此外，KSHV血清阳性与特定的性活动之间的关联没有统计学意义。总之，较高的KSHV血清阳性率被发现与男性发生性关系的日本男性比对照组，这表明KSHV感染的循环是更有效的男性与男性发生性关系的日本男性比男性谁不从事这样的性活动。医学病毒学杂志85：1046-1052，2013.© 2013 Wiley Periodicals，Inc.
Kaposi's sarcoma‐associated herpesvirus (KSHV), the etiologic agent of Kaposi's sarcoma, causes malignancies frequently in patients with acquired immunodeficiency syndrome. In the United States and Europe, KSHV infection is common among men who have sex with men. However, the seroprevalence of KSHV among men who have sex with men in Japan is unknown. In the present study, the seroprevalence of KSHV was investigated among 230 men who have sex with men and 400 age‐ and area of residence‐matched men (controls) using a mixed‐antigen (KSHV‐encoded K8.1, open reading frame 59, 65, and 73 proteins) enzyme‐linked immunosorbent assay and an immunofluorescence assay. Among the Japanese men who have sex with men, serological assays revealed that 27 (11.7%) were seropositive for KSHV; 20 (5%) of the men in the control group were also KSHV seropositive. The seroprevalence of KSHV among men who have sex with men was significantly higher than in the control group (odds ratio = 2.52, 95% confidence intervals = 1.38–4.62,P= 0.0019, Chi‐square test). Infection with the human immunodeficiency virus,Treponema pallidum, or hepatitis B and C virus did not correlate with KSHV infection. Furthermore, the association of KSHV seropositivity with specific sexual activities was not statistically significant. In conclusion, a higher KSHV seroprevalence was found among Japanese men who have sex with men than among the controls, suggesting that the circulation of KSHV infection is more efficient among men who have sex with men in Japan than among men who do not engage in such sexual activities. J. Med. Virol. 85: 1046–1052, 2013. © 2013 Wiley Periodicals, Inc.