Demographic features of idiopathic macular telangiectasia in Japanese patients
Demographic features of idiopathic macular telangiectasia in Japanese patients
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DOI：
10.1007/s10384-011-0112-5
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发表时间：
2012-03-01
影响因子：
2.4
通讯作者：
Sekiryu, Tetsuju
中科院分区：
文献类型：
--
作者：
Maruko, Ichiro;Iida, Tomohiro;Sekiryu, Tetsuju
特发性黄斑毛细血管扩张症（Idiopathic macular telangiectasia，MacTel）分为黄斑毛细血管扩张症（1型）、黄斑中心凹周围毛细血管扩张症（perifoveal telangiectasia，2型）和闭塞性毛细血管扩张症（occlusive telangiectasia，3型）。在西方国家毛细血管扩张的大多数情况下是2型。本研究报告了日本MacTel患者的临床和人口统计学特征。回顾性分析了新诊断的MacTel患者。所有患者均行荧光血管造影和光学相干断层扫描检查，其中27例34只眼为MacTel。20例患者的20只眼（74.1%）为1型，5例患者的10只眼（18.5%）为2型，2例患者的4只眼（7.4%）为3型。除了一只早期2型MacTel的眼睛外，所有眼睛均观察到中心凹毛细血管扩张和微动脉瘤。光学相干断层扫描显示1型黄斑囊样水肿，2型黄斑中心凹变薄，感光细胞内外段分界消失，3型黄斑中心凹周围视网膜各层变薄。虽然临床特征相似，但最常见的类型与西方国家不同。
Idiopathic macular telangiectasia (MacTel) is classified into aneurysmal telangiectasia (type 1), perifoveal telangiectasia (type 2) and occlusive telangiectasia (type 3). Most instances of telangiectasia in Western countries are type 2. This study reports clinical and demographic features of MacTel in Japanese patients.Newly diagnosed patients with MacTel were examined retrospectively. All patients underwent fluorescein angiography and optical coherence tomography.Thirty-four eyes of 27 patients with MacTel were included. Twenty eyes of 20 patients (74.1%) had type 1, ten eyes of five patients (18.5%) had type 2, and four eyes of two patients (7.4%) had type 3. Foveal capillary dilatation and microaneurysms were observed in all except for one eye of early stage type 2 MacTel. Optical coherence tomography revealed cystoid macular edema in type 1, temporal foveal thinning and a loss of boundary between the inner and outer segments of photoreceptors in type 2, and thinning of all retinal layers around the fovea in type 3.The most frequent among our patients was aneurysmal MacTel, whereas perifoveal MacTel was not common. Although the clinical characteristics were similar, the most common type was different from that in Western countries.