Effect of carotid or aortic baroreceptor denervation on arterial pressure during hemorrhage in conscious dogs.
Effect of carotid or aortic baroreceptor denervation on arterial pressure during hemorrhage in conscious dogs.
复制标题
颈动脉或主动脉压力感受器去神经对清醒犬出血期间动脉压的影响。
DOI：
10.1152/ajpregu.2001.280.6.r1642
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Shifflett,C
中科院分区：
文献类型：
--
作者：
Thrasher,TN;Shifflett,C
我们研究了慢性失神经支配的主动脉压力感受器（ABR;n= 6）或颈动脉压力感受器（CBR;n= 7）对犬出血时平均动脉压（MAP）和心率（HR）反应的影响。失神经支配对基础MAP、变异性和血压均无显著影响。（标准差）的MAP，或静息HR。然而，MAP断点（定义为当MAP下降超过对照的10%并且此后单调下降时移除的血液体积）在仅具有ABR功能的狗中显著减少。（12.4 ± 1.4 ml/kg）与完整状态下的体积（18.9 ± 1.8 ml/kg）相比。与此相反，在出血过程中的任何时间，与其完整的反应相比，具有CBR功能的犬的断点或MAP均无差异。在另一组犬（n= 6）中，在CBR手术和单侧去神经后再次确定反应，仅留下一个CBR（1CBR）功能。在仅给予1CBR的犬中，基础MAP和MAP的变异性没有改变，但出血时的断点（11.7 ± 1.4 ml/kg）与给予两个CBR的反应（21.2 ± 2.3 ml/kg）相比有显著差异，MAP下降到更低的水平。这些结果表明，CBR可以完全补偿出血时ABR的损失，但反之亦然;和双侧CBR输入需要对出血的正常反应。
We studied the effect of chronically denervating aortic baroreceptors (ABR;n= 6) or carotid baroreceptors (CBR;n= 7) on mean arterial pressure (MAP) and heart rate (HR) responses to hemorrhage in the dog. Neither denervation had a significant effect on basal MAP, the variability (standard deviation) of MAP, or resting HR. However, the breakpoint of MAP (defined as the volume of blood removed when MAP fell more than 10% below control and declined monotonically thereafter) was significantly reduced in dogs with only ABR functional (12.4 ± 1.4 ml/kg) compared with the volume in the intact condition (18.9 ± 1.8 ml/kg). In contrast, there was no difference in the breakpoint or the MAP at any time during hemorrhage in dogs with both CBR functional compared with their intact responses. In a different group of dogs (n= 6), responses were determined with both CBR operating and again after unilateral denervation, leaving only one CBR (1CBR) functional. Basal MAP and the variability of MAP were not altered in dogs with only 1CBR functional, but the breakpoint (11.7 ± 1.4 ml/kg) during hemorrhage was significantly different compared with responses with two CBR (21.2 ± 2.3 ml/kg), and MAP fell to much lower levels. These results indicate that the CBR can compensate fully for loss of ABR during hemorrhage but not vice versa; and bilateral CBR inputs are required for normal responses to hemorrhage.