Low-density lipoprotein adsorption for arteriosclerotic patients.
Low-density lipoprotein adsorption for arteriosclerotic patients.
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DOI：
10.1111/j.1525-1594.1996.tb04452.x
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发表时间：
1996-04
影响因子：
2.4
通讯作者：
Y. Sato;T. Agishi
中科院分区：
文献类型：
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作者：
Y. Sato;T. Agishi
目前，动脉硬化闭塞症（阿索）患者有多种治疗方法，但在某些情况下并不十分成功。使用含有硫酸葡聚糖纤维素珠的体外吸附柱进行低密度脂蛋白（LDL）单采，以集中控制伴有耐药高脂血症的阿索患者的血脂水平。一系列的单采程序对临床症状和生理学结果有显著影响，在超过80%的患者中观察到间歇性跛行改善。体积描记图和热像图读数的改善表明超过80%的患者下肢循环增加。此外，治疗改善了血液流变学，表现为血液粘度降低。在通过向先前接受治疗的患者发送调查问卷进行的后续研究中，发现即使在停止治疗后，临床症状的改善也保持良好。总之，LDL单采术被证明是一个有用的治疗工具，在阿索患者血脂水平升高。
A wide variety of treatments is now available for arteriosclerosis obliterans (ASO) patients, not very successful in some cases. Low-density lipoprotein (LDL) apheresis using an extracorporeal adsorption column containing dextran sulfate cellulose beads was applied to control lipid levels intensively in ASO patients with accompanying drug-resistant hyperlipidemia. A series of the apheresis procedures had a remarkable impact on clinical symptoms and physiological findings with improvement in intermittent claudication observed in more than 80% of the patients. Improvements in plethysmogram and thermogram readings suggested an increased circulation in lower extremities in more than 80% of patients. In addition, the treatment improved blood rheology, as evidenced by a reduction in blood viscosity. In a follow-up study made by sending a questionnaire to previously treated patients it was revealed that improvements in clinical symptoms were well maintained even after cessation of the treatment. In conclusion, LDL apheresis proved to be a useful therapeutic tool in ASO patients having elevated lipid levels.