HD2C interacts with HDA6 and is involved in ABA and salt stress response in Arabidopsis.
HD2C interacts with HDA6 and is involved in ABA and salt stress response in Arabidopsis.
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HD2C 与 HDA6 相互作用并参与拟南芥中的 ABA 和盐胁迫反应
DOI：
10.1093/jxb/ers059
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发表时间：
2012-05
影响因子：
6.9
通讯作者：
Wu K
中科院分区：
文献类型：
--
作者：
Luo M;Wang YY;Liu X;Yang S;Lu Q;Cui Y;Wu K
HD2蛋白是植物特异性组蛋白脱乙酰酶。已在拟南芥中鉴定出四种HD2蛋白，HD 2A、HD 2B、HD 2C和HD 2D。结果表明，HD 2A、HD 2B、HD 2C和HD 2D的表达受阿坝和NaCl的抑制。为了进一步研究HD2蛋白的功能，我们鉴定了两个拟南芥HD 2C T-DNA插入系hd 2c-1和hd 2c-3。与野生型植株相比，hd 2c-1和hd 2c-3植株在萌发过程中对阿坝和NaCl的敏感性增强，耐盐性降低。这些观察结果支持HD 2C在拟南芥阿坝和盐胁迫反应中的作用。此外，它表明，HD 2C与RPD 3型组蛋白脱乙酰酶，HDA 6，物理相互作用，并结合到组蛋白H3。ABA反应基因ABI 1和ABI 2在hda 6、hd 2c和hda 6/hd 2c-1双突变体植物中的表达增加，这与组蛋白H3 K9 K14乙酰化增加和组蛋白H3 K9二甲基化减少有关。综上所述，我们的研究结果表明，HD 2C与HDA 6功能相关，并通过组蛋白修饰调节基因表达。
HD2 proteins are plant specific histone deacetylases. Four HD2 proteins, HD2A, HD2B, HD2C, and HD2D, have been identified in Arabidopsis. It was found that the expression of HD2A, HD2B, HD2C, and HD2D was repressed by ABA and NaCl. To investigate the function of HD2 proteins further, two HD2C T-DNA insertion lines of Arabidopsis, hd2c-1 and hd2c-3 were identified. Compared with wild-type plants, hd2c-1 and hd2c-3 plants displayed increased sensitivity to ABA and NaCl during germination and decreased tolerance to salt stress. These observations support a role of HD2C in the ABA and salt-stress response in Arabidopsis. Moreover, it was demonstrated that HD2C interacted physically with a RPD3-type histone deacetylase, HDA6, and bound to histone H3. The expression of ABA-responsive genes, ABI1 and ABI2, was increased in hda6, hd2c, and hda6/hd2c-1 double mutant plants, which was associated with increased histone H3K9K14 acetylation and decreased histone H3K9 dimethylation. Taken together, our results suggested that HD2C functionally associates with HDA6 and regulates gene expression through histone modifications.
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影响因子：
2.9
作者：
Brosch, G;Lusser, A;Loidl, P
通讯作者：
Loidl, P
影响因子：
3.7
作者：
Pontes O;Lawrence RJ;Silva M;Preuss S;Costa-Nunes P;Earley K;Neves N;Viegas W;Pikaard CS
通讯作者：
Pikaard CS
影响因子：
16
作者：
Lawrence, RJ;Earley, K;Pikaard, CS
通讯作者：
Pikaard, CS
影响因子：
4.9
作者：
Kim, Jong-Myong;To, Taiko Kim;Seki, Motoaki
通讯作者：
Seki, Motoaki
影响因子：
56.9
作者：
Lusser, A;Brosch, G;Loidl, P
通讯作者：
Loidl, P