Quick guide to polyketide synthase and nonribosomal synthetase genes in Fusarium
Quick guide to polyketide synthase and nonribosomal synthetase genes in Fusarium
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DOI：
10.1016/j.ijfoodmicro.2012.01.018
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发表时间：
2012-04-16
影响因子：
5.4
通讯作者：
Frandsen, Rasmus J. N.
中科院分区：
文献类型：
--
作者：
Hansen, Frederik T.;Sorensen, Jens L.;Frandsen, Rasmus J. N.
镰刀菌产生过多的生物活性聚酮和非核糖体多肽，会引起动物的健康问题，并可能具有药物开发潜力。利用禾谷镰刀菌、尖孢镰刀菌、茄子镰刀菌和黄萎病镰刀菌的基因组序列，我们建立了未来聚酮合成酶(PKSS)和非核糖体肽合成酶(NRPS)命名和分类的框架。腺化和酮合酶结构域序列的序列相似性用于对已鉴定的NRPS和PKS基因进行分组。我们介绍了在已测序的镰刀菌物种及其已知产品中PKS和NRPS基因的知识现状。随着已测序真菌基因组数量的迅速增加，系统的分类将极大地帮助科学界了解不同的NRPS和PKS基因的数量及其作为已知生物活性化合物生产者的潜力。(C)2012爱思唯尔B.V.保留所有权利。
Fusarium species produce a plethora of bioactive polyketides and nonribosomal peptides that give rise to health problems in animals and may have drug development potential. Using the genome sequences for Fusarium graminearum, F. oxysporum, F. solani and F. verticillioides we developed a framework for future polyketide synthases (PKSs) and nonribosomal peptides synthetases (NRPSs) nomenclature assignment and classification. Sequence similarities of the adenylation and ketosynthase domain sequences were used to group the identified NRPS and PKS genes. We present the current state of knowledge of PKS and NRPS genes in sequenced Fusarium species and their known products. With the rapid increase in the number of sequenced fungal genomes a systematic classification will greatly aid the scientific community in obtaining an overview of the number of different NRPS and PKS genes and their potential as producers of known bioactive compounds. (C) 2012 Elsevier B.V. All rights reserved.