Traversing the NPC along the pore membrane Targeting of membrane proteins to the INM
Traversing the NPC along the pore membrane Targeting of membrane proteins to the INM
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DOI：
10.4161/nucl.2.2.14637
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发表时间：
2011-03-01
期刊：
影响因子：
3.7
通讯作者：
Kutay, Ulrike
中科院分区：
文献类型：
--
作者：
Antonin, Wolfram;Ungricht, Rosemarie;Kutay, Ulrike
内核膜（INM）容纳一组特定的整合膜蛋白，其中许多与染色质和/或在后生动物细胞中与核纤层网络相互作用。尽管 INM 与外核膜 (ONM) 和剩余的内质网 (ER) 形成膜连续体，但这些蛋白质的定位表征了核膜 (NE) 的膜区域。事实上，INM 可以被视为 ER 的高度特化的膜子域。 INM 的特定蛋白质组成是如何建立和维持的，以及这是否是通过单一的统一机制实现的，目前还不清楚。最近的实验揭示了该过程的某些方面。
The inner nuclear membrane (INM) accommodates a specific set of integral membrane proteins many of which interact with chromatin and/or in metazoan cells with the lamina network. The localization of these proteins characterizes this membrane area of the nuclear envelope (NE) despite the fact that the INM forms a membrane continuum with the outer nuclear membrane (ONM) and the remaining endoplasmic reticulum (ER). In fact, the INM can be regarded as a highly specialized membrane subdomain of the ER. How the specific protein composition of the INM is established and maintained and whether this is achieved via a single unifying mechanism is by and large unclear. Recent experiments shed light on some aspects of the process.