A case report: A rare case of infant gastrointestinal canthariasis caused by larvae of Lasioderma serricorne (Fabricius, 1792) (Coleoptera: Anobiidae)
A case report: A rare case of infant gastrointestinal canthariasis caused by larvae of Lasioderma serricorne (Fabricius, 1792) (Coleoptera: Anobiidae)
复制标题
DOI：
10.1186/s40249-016-0129-6
复制
发表时间：
2016-05-03
影响因子：
8.1
通讯作者：
Wu, Zhong-Dao
中科院分区：
文献类型：
--
作者：
Sun, Xi;Wang, Li-Fu;Wu, Zhong-Dao
背景：芫菁幼虫侵染可导致人类发生芫菁病。它是仅次于蝇蛆病的第二大重要昆虫源性疾病。据报道，有几种甲虫可在哺乳动物的胃肠道、泌尿生殖系统、鼻窦、耳朵和面部引发该疾病。烟草甲（Lasioderma serricorne）是一种分布广泛且具破坏性的害虫，通常以烟草、茶叶、豆类、谷物以及动植物标本为食。虽然此前没有该虫侵染人类的证据，但我们报道了中国一名女婴感染烟草甲的首例病例。
病例介绍：在此病例中，一名8个月大的女婴因烦躁不安、揉眼睛，在就诊前5天内有接触泥土和两次吃橙子的经历，且粪便中有“虫子”，而被收入中国广州中山大学附属第一医院。临床检查显示，脉搏、血压和体温正常，头部、颈部和胸部检查无异常。含有“虫子”的粪便标本被送往中山大学中山医学院寄生虫学系。对虫子进行了采集，通过肉眼和解剖镜进行形态学研究，针对细胞色素氧化酶亚基1（COX1）和18S rRNA基因进行聚合酶链反应（PCR）分析，对PCR产物进行序列分析检查，最后通过系统发育分析进行分类以确定其种类。根据研究结果，这些虫子被诊断为烟草甲的幼虫。
结论：本报告表明该女婴胃肠道感染了烟草甲的幼虫。在女孩接触泥土或吃橙子期间，虫卵被吞入胃中，抵御了胃酸消化，最终孵化成幼虫并引发芫菁病。8个月大的女孩免疫系统发育不完善，这可能促进了疾病的发生。本报告提示烟草甲可能意外侵染人类并导致芫菁病，当身体重要器官受累时，可能会对婴儿和老年患者造成严重损害。一旦患者被诊断患有芫菁病，应及时治疗。
Background: Canthariasis is a disease of humans caused by the infestation of beetle larvae. It is the second important insectal disease after myiasis. Several species of beetles are reported to cause the disease in gastrointestinal tract, urogenital system, nasal sinuses, ears and faces of mammals. The cigarette beetle Lasioderma serricorne is a widespread and destructive pest that usually feeds on tobacco, tea, beans, cereal grains, and animal and plant specimen. While there was no previous evidence of human infestation by this worm, we report the first case of L. serricorne infestation in a baby girl in China.Case presentation: Here the case, an eight-month-old baby girl with irritable feeling, rubbing eyes, history of contact with mud and eating oranges twice during five days before attendance, and having "worms" in her stool was admitted to the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. The clinical examination revealed that the pulse rate, blood pressure and temperature were regular, and the examination of the head, neck, and chest were unremarkable. The stool specimens containing "worms" were sent to the Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University. The worms were recovered, studied morphologically using naked eyes and anatomical lens, PCR analyzed targeting cytochrome oxidase subunit 1 (COX1) and 18S rRNA genes, examined by sequence analyses of the PCR products and finally classified by phylogenetic analysis to identify their species. Based on the findings, the worms were diagnosed as the larvae of L. serricorne.Conclusion: This report implies that the baby had an infestation with the larvae of L. serricorne in the gastrointestine. During contact with mud or eating oranges by the girl, worm eggs were swallowed into the stomach and resisted gastric acid digestion which eventually hatched into larvae and caused canthariasis. The 8 months girl had underdeveloped immune system which might facilitate the disease. This report implicates that L. serricorne can infest human accidentally and cause canthariasis that may lead to severe damage to infant and older patient upon involvement of important organs of the body. The patients once diagnosed having canthariasis should be treated in time.