Particulate delivery systems for vaccination against bioterrorism agents and emerging infectious pathogens.
Particulate delivery systems for vaccination against bioterrorism agents and emerging infectious pathogens.
复制标题
DOI：
10.1002/wnan.1403
复制
发表时间：
2017-01
影响因子：
8.6
通讯作者：
Moon, James J.
中科院分区：
文献类型：
--
作者：
Fan, Yuchen;Moon, James J.
生物恐怖主义制剂很容易传播，死亡率很高，并引起衰弱性疾病，对国家安全和公共健康构成重大威胁。最近在西非爆发的埃博拉病毒和巴西持续爆发的寨卡病毒目前正在整个拉丁美洲蔓延，这些都是新出现的传染性病原体在全球范围内引发广泛恐惧以及经济和社会混乱的例子。预防性疫苗将为传染性病原体和生物战剂提供有效的对策。然而，依赖于减毒或灭活疫苗的传统方法因其不可接受的反应原性水平和安全问题而受到阻碍，而基于亚单位抗原的疫苗则面临着次优的免疫原性和功效。相比之下，颗粒疫苗递送系统具有关键优势，包括有效且稳定地递送亚单位抗原、共同递送佐剂分子以增强免疫反应、由于使用生物相容性生物材料而导致的低反应原性，以及在系统和粘膜组织中引发体液和细胞免疫的强大效率。因此，疫苗纳米颗粒和微粒是生物防御疫苗临床开发的有前途的平台。在这篇综述中，我们总结了开发针对生物恐怖分子和新出现的传染性病原体的颗粒疫苗输送系统的研究工作的现状。
Bioterrorism agents that can be easily transmitted with high mortality rates and cause debilitating diseases pose major threats to national security and public health. The recent Ebola virus outbreak in West Africa and ongoing Zika virus outbreak in Brazil, now spreading throughout Latin America, are case examples of emerging infectious pathogens that have incited widespread fear and economic and social disruption on a global scale. Prophylactic vaccines would provide effective countermeasures against infectious pathogens and biological warfare agents. However, traditional approaches relying on attenuated or inactivated vaccines have been hampered by their unacceptable levels of reactogenicity and safety issues, whereas subunit antigen-based vaccines suffer from suboptimal immunogenicity and efficacy. In contrast, particulate vaccine delivery systems offer key advantages, including efficient and stable delivery of subunit antigens, co-delivery of adjuvant molecules to bolster immune responses, low reactogenicity due to the use of biocompatible biomaterials, and robust efficiency to elicit humoral and cellular immunity in systemic and mucosal tissues. Thus, vaccine nanoparticles and microparticles are promising platforms for clinical development of biodefense vaccines. In this review, we summarize the current status of research efforts to develop particulate vaccine delivery systems against bioterrorism agents and emerging infectious pathogens.
登录
查看更多内容
影响因子：
--
作者：
Bavaro, Mary F
通讯作者：
Bavaro, Mary F
影响因子：
5.5
作者：
Camacho, A. I.;de Souza, J.;Gamazo, C.
通讯作者：
Gamazo, C.
DOI：
10.1016/0035-9203(52)90042-4
发表时间：
1952-01-01
影响因子：
2.2
作者：
DICK, GWA;KITCHEN, SF;HADDOW, AJ
通讯作者：
HADDOW, AJ
DOI：
10.1007/s40259-013-0046-1
发表时间：
2013-12
期刊：
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy
影响因子：
--
作者：
Choi JH;Croyle MA
通讯作者：
Croyle MA
DOI：
10.4049/jimmunol.1000768
发表时间：
2010-09-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Demento SL;Bonafé N;Cui W;Kaech SM;Caplan MJ;Fikrig E;Ledizet M;Fahmy TM
通讯作者：
Fahmy TM