Proteomics database in chronic kidney disease.
Proteomics database in chronic kidney disease.
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DOI：
10.1053/j.ackd.2010.09.005
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发表时间：
2010-11
影响因子：
2.9
通讯作者：
Tadashi Yamamoto
中科院分区：
文献类型：
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作者：
Tadashi Yamamoto
本文讨论了用于人体肾脏组织和尿液蛋白质组学分析的数据库。以基因和蛋白质为中心的通用数据库与人类肾脏组织和尿液蛋白质组数据库的整合可能为肾脏学的研究打开一扇新的窗口。存在于肾脏和尿液中的蛋白质为研究肾脏功能和疾病提供了基本工具。通过比较健康人群和患病人群之间的数据库，我们可能能够确定以下内容：参与肾脏疾病发展的蛋白质，参与CKD进展的蛋白质，或肾脏疾病发展或CKD进展的新生物标志物候选蛋白质。
Databases which are useful for proteomic analysis of human kidney tissue and urine have been discussed in this article. Integration of the gene-centric and protein-centric general databases with those of human kidney tissue and urine proteomes may open a new window for research in nephrology. Proteins present in the kidney and urine provide basic tools for investigation of kidney function and disease. By comparing such databases between the healthy and diseased populations, we may be able to identify the following: proteins involved in the development of renal disease, proteins involved in progression of CKD, or new biomarker candidate proteins for either the development of renal disease or the progression of CKD.