Building biorepositories in the midst of a pandemic.
Building biorepositories in the midst of a pandemic.
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在大流行期间建立生物储存库。
DOI：
10.1017/cts.2021.6
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发表时间：
2021-02-05
影响因子：
2.6
通讯作者：
Elemento O
中科院分区：
文献类型：
--
作者：
Croker JA;Patel R;Campbell KS;Barton-Baxter M;Wallet S;Firestein GS;Kimberly RP;Elemento O
生物标本库在生物机制的研究、疾病相关生物标志物的鉴定、诊断测定的进展、微生物进化的识别以及新的治疗靶点的表征方面发挥着至关重要的作用。它们依赖于科学需求、监管监督、收集、处理和跟踪中的质量控制以及与强大的表型信息的联系的复杂整合。2019冠状病毒病大流行放大了许多这些考虑因素，并揭示了新的挑战，而学术健康中心正试图适应前所未有的临床需求和100多年来从未见过的更高的研究限制。疫情要求快速了解SARS-CoV-2以开发诊断和治疗方法，这促使人们迫切需要获得高质量、特征良好的COVID-19相关生物标本。我们调查了60个临床和转化科学奖（CTSA）中心，以更好地了解生物库在COVID-19大流行之前和应对COVID-19大流行时遇到的策略和障碍。反馈信息显示，生物储存模式、生物制品获取和同意过程发生了重大转变，从制造商发起的协议和机构协议相结合，转变为企业服务战略。CTSA中心有充分的条件利用现有的能力和专门知识，通过支持生物储存库管理方面的体制办法，迅速应对这场危机的科学需求。
Biospecimen repositories play a vital role in enabling investigation of biologic mechanisms, identification of disease-related biomarkers, advances in diagnostic assays, recognition of microbial evolution, and characterization of new therapeutic targets for intervention. They rely on the complex integration of scientific need, regulatory oversight, quality control in collection, processing and tracking, and linkage to robust phenotype information. The COVID-19 pandemic amplified many of these considerations and illuminated new challenges, all while academic health centers were trying to adapt to unprecedented clinical demands and heightened research constraints not witnessed in over 100 years. The outbreak demanded rapid understanding of SARS-CoV-2 to develop diagnostics and therapeutics, prompting the immediate need for access to high quality, well-characterized COVID-19-associated biospecimens. We surveyed 60 Clinical and Translational Science Award (CTSA) hubs to better understand the strategies and barriers encountered in biobanking before and in response to the COVID-19 pandemic. Feedback revealed a major shift in biorepository model, specimen-acquisition and consent process from a combination of investigator-initiated and institutional protocols to an enterprise-serving strategy. CTSA hubs were well equipped to leverage established capacities and expertise to quickly respond to the scientific needs of this crisis through support of institutional approaches in biorepository management.
DOI：
10.1093/jamia/ocaa196
发表时间：
2021-03-01
影响因子：
6.4
作者：
Haendel, Melissa A.;Chute, Christopher G.;Gersing, Ken R.
通讯作者：
Gersing, Ken R.