Scaling of traction forces with the size of cohesive cell colonies.
Scaling of traction forces with the size of cohesive cell colonies.
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DOI：
10.1103/physrevlett.108.198101
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发表时间：
2012-05-11
影响因子：
8.6
通讯作者：
Dufresne ER
中科院分区：
文献类型：
--
作者：
Mertz AF;Banerjee S;Che Y;German GK;Xu Y;Hyland C;Marchetti MC;Horsley V;Dufresne ER
为了了解组织的力学特性是如何从多个细胞的相互作用中产生的，我们测量了1-27个细胞粘附在软基质上的内聚菌落的牵引应力。我们发现，牵引应力一般局限于群体的外围，总牵引力随群体半径的变化而变化。对于大的菌落大小，缩放似乎接近线性，这表明出现了10−3 N/m量级的表观表面张力。一个简单的细胞集落模型作为一个收缩弹性介质与基底耦合，捕获了牵引力的空间分布和牵引力随集落大小的缩放。
To understand how the mechanical properties of tissues emerge from interactions of multiple cells, we measure traction stresses of cohesive colonies of 1–27 cells adherent to soft substrates. We find that traction stresses are generally localized at the periphery of the colony and the total traction force scales with the colony radius. For large colony sizes, the scaling appears to approach linear, suggesting the emergence of an apparent surface tension of the order of 10−3 N/m. A simple model of the cell colony as a contractile elastic medium coupled to the substrate captures the spatial distribution of traction forces and the scaling of traction forces with the colony size.